DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	550	Identity:	144/550 - (26%)
Similarity:	255/550 - (46%)	Gaps:	77/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYP-------AKIDGVRHIRV 77
            :::|.:..:| |.|... |.:..:|.:|:|||:|.|.||::..:..|       |:.|  .|:..
Zfish    15 VDVGWSGRVL-VMPGEY-SHWHNMRAIIEALVDRNHSVTVLVSSSSPTVPHTQKARFD--YHVFK 75

  Fly    78 PMLNQLMQNLMKND---QFFDALGDKWREGVLVSTIFYN-------VSHAILNNNGVQMLMRDKS 132
            ..:::....::.:|   .:......|...|.|:..:..|       |..::|.|:
Zfish    76 VNMDKEEAKVIWSDFTHLWMKETDSKLERGFLIWRVMSNFRRLAADVCRSLLQND---------- 130

  Fly   133 IRFDMI-MVEASHLDALYG---------LAEFYNATLLGISCMHMTWHIDYLAGNL-APSVYEP- 185
               |:: |:..||.|.|:.         :|:..|...:....:...:..:.:.|.: ||..|.|
Zfish   131 ---DLLQMLGESHYDVLFSDPMMPCSDLMAQTLNIPQVISLRLTFAYTFERMCGQMPAPPSYVPA 192

  Fly   186 ISPNGFALDN-TFLSRWSNWIYITEEKLLERLVFRPAQV----RLFKKFFGYPAEKLDELRARFS 245
            ::......|. :|:.|..|.:..    .:...|||...:    ||:.:..|.|. .:.|...:..
Zfish   193 VALTDHLTDRMSFMERVENMLLY----FIHTTVFRLNTMLTVDRLYTEIRGKPT-TMCETMGKAD 252

  Fly   246 VILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYL 309
            :.|:.:::.....|...||...|.|:| .:|.:|...|:::::..: :||.:.||:|.  :||.|
Zfish   253 IWLIRTYWDFEYPRPFPPNFKFVGGLH-CKPAKPLSKEMEEFVQSSGDHGVVVFSLGS--MIKNL 314

  Fly   310 PENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVM 374
            .......:.....|:.|:|:|:.........:.|..:.|.:||..:|.||..:.||||||...:.
Zfish   315 TSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLY 379

  Fly   375 EAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMA 439
            |||.:||||:|||||.||.:|:..::..|.|.|||.|.|.:..|::.:|.:|.||||.:....::
Zfish   380 EAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRLS 444

  Fly   440 ASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLD---------SILTF-GVRL 494
            ....|:||.|||.|::|.|:.:||:...|:|:...|:...:|:.||         :::|| .|:.
Zfish   445 RIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAALITFLWVKA 509

  Fly   495 GCVCGSLIFLGWRLYQKNR-NRHTRLQERE 523
            .|      ||..|..:|.| .|.|:..:.|
Zfish   510 CC------FLFRRCVRKTRPERKTQKSKNE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	124/474 (26%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	138/529 (26%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	78/233 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860