DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt5b4

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001074161.1	Gene:	ugt5b4 / 791210	ZFINID:	ZDB-GENE-070112-2332	Length:	531	Species:	Danio rerio

Alignment Length:	547	Identity:	140/547 - (25%)
Similarity:	252/547 - (46%)	Gaps:	108/547 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPAD------------ 64
            |||.:...:|.|   |:| |||.. .|.:..:..|::||..:||.:|::..:|
Zfish    16 LLLVMAPVVESG---NVL-VFPVD-GSHWVNMNILVEALHAKGHNITVIRMSDSWYIKEFSPHYT 75

  Fly    65 -----------------YPAKI-----DGVRHIRVPMLNQLMQ--------------NLMKNDQF 93
                             :.:::     ||....|:.:..::.|              |::::.|.
Zfish    76 SITLKSSGGFSEDILETFASRLITILRDGSTWGRLKLEMEMWQSSLKIMETEREMIINMIEDQQL 140

  Fly    94 FDALGDKWREGVLVSTIFYNVSHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNAT 158
            .|:|                                 |..::|:.:.:    .|:||.....|..
Zfish   141 IDSL---------------------------------KKTKYDLFLTD----PAMYGGVILGNYL 168

  Fly   159 LLGISCMHMTWHIDYLAGN--LAPS--VYEPISPNGFALDNTFLSRWSNWI-YITEEKLLERLVF 218
            .|.| ..::.|.| :..|:  :|||  .|.|::........:||.|..|.: ||..|..:..|:
Zfish   169 KLPI-VYNVRWAI-FGEGHFVIAPSPLSYVPVAMLELPDRMSFLERVKNVVMYIITETQIAFLI- 230

  Fly   219 RPAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAE 283
            .|....|.::|.| |...|..|.....:.|..:.|.....|..:|||:.:||.. .:|.:|...:
Zfish   231 APTYNVLCERFIG-PGVNLFNLVQGADLWLHRADFVFEYPRPTMPNIVYMAGFQ-CKPSKPLPKD 293

  Fly   284 LQKYLDEA-EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVM 347
            |:.::..: :||.|..|:|  .:|..||:::.:.:...|.::.|::||:.:....:....|..:|
Zfish   294 LEDFVQSSGDHGVIVMSLG--TIIGQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIM 356

  Fly   348 DKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPND 412
            |.:||..:|.||..|.|:.|||...|.|||.:|||::|..|.|||.:|:.::::.|.||.:|...
Zfish   357 DWMPQNDLLGHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFAT 421

  Fly   413 LNADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIP 477
            ::.::.::|:||:|.:|||.:..:.::...:|.|:.|||.||:|.|:.:|::..:|:|....::|
Zfish   422 MDKESFLKTVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMP 486

  Fly   478 LMRYYRLDSILTFGVRLGCVCGSLIFL 504
            ...|:.:|.||   |.:..|  |||.|
Zfish   487 WYSYHSVDVIL---VLISAV--SLIIL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	122/493 (25%)
ugt5b4	NP_001074161.1	egt	12..501	CDD:223071	135/536 (25%)
ugt5b4	NP_001074161.1	UDPGT	27..531	CDD:278624	136/536 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584512
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.790