DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	516	Identity:	135/516 - (26%)
Similarity:	233/516 - (45%)	Gaps:	122/516 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LIKALVERGHKV-------------------TMVTP----------ADYPAKI------------ 69
            |||||..:||.|                   |:..|          ||:..|:
Zfish    67 LIKALHGQGHTVDVIRNANSWFIKENSTYYDTITIPNTKGWDEEFAADFVYKMIKYEKEKGSWLS 131

  Fly    70 ---------DGVRHIRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAILNNNGVQ 125
                     |.|:... .|:.||:.|::.:::....|.:|..:.:|...::           |..
Zfish   132 IVRLYLNVFDAVKKTH-EMVCQLITNILDSEEILKMLNEKQYDLMLTDPVW-----------GTG 184

  Fly   126 MLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTW------HIDYLAGNLAPS--V 182
            :::..| ::..|:                ||          :.|      |.|     :|||  .
Zfish   185 IILAHK-LKLPMV----------------YN----------VRWTTTGEGHFD-----IAPSPMS 217

  Fly   183 YEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVI 247
            |.||:.:|.....:|..|..|:.:.    ||..|......|:.::..    .:|....|..|..:
Zfish   218 YIPITGSGNTDRMSFFQRLKNYFFY----LLLDLQLSHFNVKQYQAI----CDKYFTSRVNFHEL 274

  Fly   248 LVNSHFSMGRV-------RANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDI 304
            |..:...:.||       |..:||||.:.|.. ..|.:|...:|:.::..: :||.|..|:|.
Zfish   275 LQGADLWLMRVDFVFEFPRPTMPNIIYIGGFQ-CPPAKPLPHDLEDFMQSSGDHGVIVMSLGS-- 336

  Fly   305 LIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGG 369
            ||..||||:..::...|.::.|:|||:......:..|.|..::|.:||:.:|.||..::||:|||
Zfish   337 LIGNLPENVTAEIAAAFARLPQKVIWRYTGKKPSTLSNNTLMVDWMPQKDLLGHPKTKVFISHGG 401

  Fly   370 LQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQR 434
            ...|:||:.:|||::|:|.||||::|:.|:|..|.||:|...||..:||...|:|::..|||...
Zfish   402 TNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKLLSIADLGENTLHAAIQEVINEPSYRLN 466

  Fly   435 AKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILT-FGVRL 494
            ..:::...:|:|:.|||:||:|.|:.:|::..:|:|....::|...|:.:|.::| |.|.|
Zfish   467 MHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVVVTLFAVVL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	126/483 (26%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	135/516 (26%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	85/243 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585094
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690