DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and UGT2B17

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001068.1	Gene:	UGT2B17 / 7367	HGNCID:	12547	Length:	530	Species:	Homo sapiens

Alignment Length:	533	Identity:	136/533 - (25%)
Similarity:	258/533 - (48%)	Gaps:	64/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPAD----YPA 67
            |::..||:.|:.|...|....:| |:|... |.:..::.:::.||:|||:|.::|.:.    ..:
Human     5 WMSVFLLMQLSCYFSSGSCGKVL-VWPTEY-SHWINMKTILEELVQRGHEVIVLTSSASILVNAS 67

  Fly    68 KIDGVRHIRVPMLNQLMQNLMKND--QFFDALGDKWREGVLVSTIF---------------YNV- 114
            |...::      |.....:|.|||  .||..:.|:|...:..:|.:               ||:
Human    68 KSSAIK------LEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIK 126

  Fly   115 --SHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMH-MTWHIDYL-- 174
              ..|:||...::.|...|   ||:::.     ||:....|.. |.||.|..:: :.:.:.|.
Human   127 LCEDAVLNKKLMRKLQESK---FDVLLA-----DAVNPCGELL-AELLNIPFLYSLRFSVGYTVE 182

  Fly   175 ---AGNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFF----GY 232
               .|.|.|..|.|:..:..:....|:.|..|.||:    |.....|:...::.:.:|:    |.
Human   183 KNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYM----LYFDFWFQAYDLKKWDQFYSEVLGR 243

  Fly   233 PAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAI 296
            |. .|.|...:..:.|:.:::.....|..:||:..|.|:| .:|.:|...|:::::..: |:|.:
Human   244 PT-TLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLH-CKPAKPLPKEMEEFVQSSGENGIV 306

  Fly   297 YFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNL 361
            .||:|.  :|..:.|.....:.....|:.|:|:|:.:.........|..:...:||..:|.||..
Human   307 VFSLGS--MISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKT 369

  Fly   362 RLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELL 426
            :.||||||...:.|||.:|:||:|:|||.||.:||..::..|.|..:|...:::..|:..:|.::
Human   370 KAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVI 434

  Fly   427 ENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFG 491
            .:|.|.:...:::....|:|:.|||.|::|.|:.:|::...|:|:....:..::|:.|| ::.|
Human   435 NDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLD-VIAF- 497

  Fly   492 VRLGCVCGSLIFL 504
             .|.|| .::||:
Human   498 -LLACV-ATMIFM 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	119/474 (25%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	130/514 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150259
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690