Protein Alignment Ugt303B2 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 138/546 - (25%)
• Similarity: 259/546 - (47%)
• Gaps: 90/546 - (16%)

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPAD------- 64
            |.:..||:.|:.|...|....:| |:|... |.:..::.:::.||:|||:||::|.:.
Human     5 WTSVFLLIQLSCYFSSGSCGKVL-VWPTEY-SHWINMKTILEELVQRGHEVTVLTSSASTLVNAS 67

  Fly    65 ---------YPAKIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVSTI---------- 110
                     ||..:         ..|.|..:|:|       :.|:|..||..:|.
Human    68 KSSAIKLEVYPTSL---------TKNYLEDSLLK-------ILDRWIYGVSKNTFWSYFSQLQEL 116

  Fly   111 ---FYNVSH-----AILNNNGVQMLMRDKSIRFDMIMVEASHLDALYG----LAEFYNATLLGIS 163
               :|:.|:     |:||.   :::|:.:..:||:|:.     |||..    |||.:|...|
Human   117 CWEYYDYSNKLCKDAVLNK---KLMMKLQESKFDVILA-----DALNPCGELLAELFNIPFL--- 170

  Fly   164 CMHMTWHIDYL-----AGNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQV 223
             ..:.:.:.|.     .|.|.|..|.|:..:..:....|:.|..|.|::    |.....|:...:
Human   171 -YSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHM----LYFDFWFQIYDL 230

  Fly   224 RLFKKFF----GYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAEL 284
            :.:.:|:    |.|. .|.|...:..:.|:.:::.....|..:||:..|.|:| .:|.:|...|:
Human   231 KKWDQFYSEVLGRPT-TLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLH-CKPAKPLPKEM 293

  Fly   285 QKYLDEA-EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMD 348
            ::::..: |:|.:.||:|.  :|..:.|.....:.....|:.|:|:|:.:.........|..:..
Human   294 EEFVQSSGENGIVVFSLGS--MISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYK 356

  Fly   349 KVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDL 413
            .:||..:|.||..:.||||||...:.|||.:|:||:|:|||.||.:||..::..|.|..:|...:
Human   357 WLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTM 421

  Fly   414 NADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPL 478
            ::..|:..:|.::.:|.|.:...:::....|:||.|||.|::|.|:.:|::...|:|:....:..
Human   422 SSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTW 486

  Fly   479 MRYYRLDSILTFGVRLGCVCGSLIFL 504
            ::|:.|| ::.|  .|.|| .::||:
Human   487 IQYHSLD-VIAF--LLACV-ATVIFI 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	121/487 (25%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	132/527 (25%)