Protein Alignment Ugt303B2 and UGT2B10

DIOPT Version :9

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 134/537 - (24%)
• Similarity: 259/537 - (48%)
• Gaps: 57/537 - (10%)

  Fly    12 LLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVT--------PAD---- 64
            ||:.|:.|...|....:| |:.... |.:..::.::|.||:|||:||::.        |.|
Human     9 LLIQLSFYFSSGSCGKVL-VWAAEY-SLWMNMKTILKELVQRGHEVTVLASSASILFDPNDSSTL 71

  Fly    65 ----YPAKIDGVRHIRVPMLNQLMQNL--MKNDQFFDALGDKWREGVLVSTIFYNVSHAILNNNG 123
                ||..:.......:.|  ||::.|  ::.|.|:.....:......::.|..|....:::|.
Human    72 KLEVYPTSLTKTEFENIIM--QLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNK- 133

  Fly   124 VQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHID-YLAGNLAPSVYEPIS 187
             :::.:.:..|||::..:| :|.....|||.:|...:........:..: :..|.:.|..|.|:.
Human   134 -KLMKKLQESRFDIVFADA-YLPCGELLAELFNIPFVYSHSFSPGYSFERHSGGFIFPPSYVPVV 196

  Fly   188 PNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFF----GYPAEKLDELRARFSVIL 248
            .:..:...||:.|..|.:|:    |.....|:...::.:.:|:    |.|. .|.|...:..:.|
Human   197 MSKLSDQMTFMERVKNMLYV----LYFDFWFQIFNMKKWDQFYSEVLGRPT-TLSETMRKADIWL 256

  Fly   249 VNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYLPEN 312
            :.:.::.......:||:..|.|:| .:|.:|...|:::::..: |:|.:.||:|.  ::..:.|.
Human   257 MRNSWNFKFPHPFLPNVDFVGGLH-CKPAKPLPKEMEEFVQSSGENGVVVFSLGS--MVSNMTEE 318

  Fly   313 MQKQLLLVFLQMKQRVIWKSELSMLANKSE----NIYVMDKVPQRMVLAHPNLRLFITHGGLQSV 373
            ....:.....::.|:|:|:.:    .||.:    |..:...:||..:|.||..|.||||||...:
Human   319 RANVIATALAKIPQKVLWRFD----GNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGI 379

  Fly   374 MEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEM 438
            .|||.:|:||:|:||||||.:||..::..|.|..:|.|.:::..|:..:|.::.:|||.:...::
Human   380 YEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKL 444

  Fly   439 AASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSL-- 501
            :....|:|:.|||.|::|.|:.:|::...|:|:....:...:|:.||.|   |..|.||...|
Human   445 SRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVI---GFLLACVATVLFI 506

  Fly   502 -----IFLGWRLYQKNR 513
                 :|..|:..:|.:
Human   507 ITKCCLFCFWKFARKGK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	115/467 (25%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	129/523 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150493
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690