Protein Alignment Ugt303B2 and UGT2B7

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 134/558 - (24%)
• Similarity: 257/558 - (46%)
• Gaps: 93/558 - (16%)

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPAD------- 64
            |.:..||:.|:.....|....:| |:.... |.:..::.::..|::|||:||::..:.
Human     5 WTSVILLIQLSFCFSSGNCGKVL-VWAAEY-SHWMNIKTILDELIQRGHEVTVLASSASILFDPN 67

  Fly    65 ---------YPAKIDGVRHIRVPMLNQLMQNL-----MKNDQF---FDALGDKWREGVLVSTIFY 112
                     ||..:     .:..:.|.:||.:     :..|.|   |..:.:       :.:||.
Human    68 NSSALKIEIYPTSL-----TKTELENFIMQQIKRWSDLPKDTFWLYFSQVQE-------IMSIFG 120

  Fly   113 NVSHA----ILNNNGVQMLMRDKSIRFDMIMVEA----SHLDALYGLAEFYNATLLGISCMHMTW 169
            :::..    :::|.  :.:.:.:..|||:|..:|    |.|     |||.:|...:    ..:::
Human   121 DITRKFCKDVVSNK--KFMKKVQESRFDVIFADAIFPCSEL-----LAELFNIPFV----YSLSF 174

  Fly   170 HIDYL-----AGNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKF 229
            ...|.     .|.:.|..|.|:..:......||:.|..|.||:    |.....|....::.:.:|
Human   175 SPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYV----LYFDFWFEIFDMKKWDQF 235

  Fly   230 F----GYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDE 290
            :    |.|. .|.|...:..|.|:.:.::.......:||:..|.|:| .:|.:|...|::.::..
Human   236 YSEVLGRPT-TLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLH-CKPAKPLPKEMEDFVQS 298

  Fly   291 A-EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSE----NIYVMDKV 350
            : |:|.:.||:|.  ::..:.|.....:.....|:.|:|:|:.:    .||.:    |..:...:
Human   299 SGENGVVVFSLGS--MVSNMTEERANVIASALAQIPQKVLWRFD----GNKPDTLGLNTRLYKWI 357

  Fly   351 PQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNA 415
            ||..:|.||..|.||||||...:.|||.:|:||:|:|||.||.:||..::..|.|..:|.|.:::
Human   358 PQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSS 422

  Fly   416 DTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMR 480
            ..|:..:|.::.:|||.:...:::....|:|:.|||.|::|.|:.:|::...|:|:...::...:
Human   423 TDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQ 487

  Fly   481 YYRLDSILTFGVRLGCVCGSL-------IFLGWRLYQK 511
            |:.||.|   |..|.||...:       :|..|:..:|
Human   488 YHSLDVI---GFLLVCVATVIFIVTKCCLFCFWKFARK 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	116/485 (24%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	129/539 (24%)