Protein Alignment Ugt303B2 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 135/542 - (24%)
• Similarity: 257/542 - (47%)
• Gaps: 83/542 - (15%)

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMV----------- 60
            |.:..||:.|:.|...|....:| |:|... |.:..::.::..||:|||:||::
Human     5 WTSALLLIQLSCYFSSGSCGKVL-VWPTEF-SHWMNIKTILDELVQRGHEVTVLASSASISFDPN 67

  Fly    61 TPAD-----YPAKIDGVRHIRVPMLNQLMQNLMK------NDQFFDALGDKWREGVLVSTIFYNV 114
            :|:.     ||..:....      ...:::.|:|      .|.|       |.....|..|.:..
Human    68 SPSTLKFEVYPVSLTKTE------FEDIIKQLVKRWAELPKDTF-------WSYFSQVQEIMWTF 119

  Fly   115 SHA-------ILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMT---- 168
            :..       |::|.  :::.:.:..|||:::.     ||::...|.. |.||.|..::..
Human   120 NDILRKFCKDIVSNK--KLMKKLQESRFDVVLA-----DAVFPFGELL-AELLKIPFVYSLRFSP 176

  Fly   169 -WHID-YLAGNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFF- 230
             :.|: :..|.|.|..|.|:..:..:...||:.|..|.||:    |.....|:...::.:.:|:
Human   177 GYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYV----LYFEFWFQIFDMKKWDQFYS 237

  Fly   231 ---GYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA- 291
               |.|. .|.|..|:..:.|:.:::........:||:..|.|:| .:|.:|...|:::::..:
Human   238 EVLGRPT-TLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLH-CKPAKPLPKEMEEFVQSSG 300

  Fly   292 EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSE----NIYVMDKVPQ 352
            |:|.:.||:|.  ::....|.....:.....::.|:|:|:.:    .||.:    |..:...:||
Human   301 ENGVVVFSLGS--MVSNTSEERANVIASALAKIPQKVLWRFD----GNKPDTLGLNTRLYKWIPQ 359

  Fly   353 RMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADT 417
            ..:|.||..|.||||||...:.|||.:|:||:|:|||.||.:||..::..|.|..||.:.:::..
Human   360 NDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTD 424

  Fly   418 LIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYY 482
            |:..:|.::.:|.|.:.|.:::....|:|:.|||.|::|.|:.:|::...|:|:...::...:|:
Human   425 LLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYH 489

  Fly   483 RLDSILTFGVRLGCVCGSLIFL 504
            .||   ..|..|.|| .::||:
Human   490 SLD---VTGFLLACV-ATVIFI 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	118/483 (24%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	129/523 (25%)