DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	527	Identity:	137/527 - (25%)
Similarity:	250/527 - (47%)	Gaps:	95/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VFPYRIPSPFQMVRPLIKALVERGHKVTMVTPAD--YPAKIDGVRHIRVPMLNQLMQNLMKNDQF 93
            |||.. .|.:..::.||:.|..:||.||:|.|::  |                     :.:...|
Zfish    26 VFPLD-GSHWVNMKVLIEELHRKGHNVTVVRPSNSWY---------------------IKEESPF 68

  Fly    94 FDALG-------DKWREGVLVSTIF------YNVSHAI------------LNNNGVQM---LMRD 130
            :.::.       |:...|:|::.:.      |.|.:.:            ::.:.:||   ::.|
Zfish    69 YSSITIPNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMDRMLED 133

  Fly   131 KSI-------RFDMIMVEASHLDALYG---LAEFYNATLLGISCMHMTWHID---YLAGNLAPSV 182
            :.:       :||:::.:    .|:.|   ||..:|..|:    .::.|.|.   :.|  :|||.
Zfish   134 EKVMNSIQDAKFDVVLAD----PAVGGGPILAYKFNIPLV----FNVRWTIQGEGHFA--IAPSP 188

  Fly   183 YEPISPNGFALDN--TFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFS 245
            ...|...|..|.:  :||.|..|.:.....::..:::..|.......|.|| |......|.....
Zfish   189 LSYIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFG-PNVTYFSLFQDAD 252

  Fly   246 VILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYL 309
            :.|:.:.|:....|..:|||:.::|.. .:|.:|...:|:|:::.: |||.|..|:|  .||..|
Zfish   253 IWLMRNDFTFEFPRPTMPNIVYMSGFQ-CKPAKPLPNDLEKFVESSGEHGVIVMSLG--TLIAQL 314

  Fly   310 PENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVM 374
            |::|...:...|.::.|:|||:...........|..:::.:||..:|.||.:::|:.|||...:.
Zfish   315 PQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGNNTLLVEWLPQNDLLGHPQIKVFVAHGGTNGIQ 379

  Fly   375 EAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMA 439
            |||.:|||:|||||.|||.:|:.|::..|.||::|...|:....:|.:||:|.||||.:..:.::
Zfish   380 EAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPSYRENMQRLS 444

  Fly   440 ASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILT-------FGVRLG-- 495
            ....|:|:.|||.|::|.|:.:||:...|:|.....:..:.|:.:|.|||       |.:.:|
Zfish   445 KLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVILTLMVTGFVFALMIGYT 509

  Fly   496 ----CVC 498
                |:|
Zfish   510 IKYFCLC 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	125/478 (26%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	137/527 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584440
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690