Protein Alignment Ugt303B2 and UGT2A2

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 135/548 - (24%)
• Similarity: 245/548 - (44%)
• Gaps: 99/548 - (18%)

  Fly    10 FGLLLHLNLYL-ELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTM-------------- 59
            |..:|..||.| |:..:.|:| ::| ...|.:..::.:::.|::|.|.||:
Human    13 FVQMLVFNLTLTEVVLSGNVL-IWP-TDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPD 75

  Fly    60 ------VTPADY-PAKIDG---------VRHIRVPM--------LNQLMQNLMKNDQFFDALGDK 100
                  |.|..| .:.||.         :.|...|:        |.:|:      |.||. :..:
Human    76 SPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLL------DTFFQ-INIQ 133

  Fly   101 WREGVLVSTIFYNVSHAILNNNGVQMLMRDK-SIRFDMIMVEASHLDALYGLAEFYNATLLGISC 164
            ..:|||.:....    |.|...|..:|:.|. :|..|::.::.. :..:|.| .|..|:.:...|
Human   134 LCDGVLKNPKLM----ARLQKGGFDVLVADPVTICGDLVALKLG-IPFMYTL-RFSPASTVERHC 192

  Fly   165 MHMTWHIDYLAGNLAPSVYEPISPN---GFALDNT---------FLSRWSNWIYITEEKLLERLV 217
            ..:...:.|:     |:....::..   |..:.||         |.|.|..|
Human   193 GKIPAPVSYV-----PAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEW------------- 239

  Fly   218 FRPAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGA 282
                 ...:.|..|.|. .|.|...:..:.|:.:::.....|..:||...|.|:| .:|.:|...
Human   240 -----NSYYSKILGRPT-TLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLH-CKPAKPLPK 297

  Fly   283 ELQKYLDEA-EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYV 346
            |:::::..: ::|.:.||:|.  ::|.|.|.....:.....|:.|:|:|:.:....|....|..:
Human   298 EMEEFIQSSGKNGVVVFSLGS--MVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQL 360

  Fly   347 MDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPN 411
            .|.:||..:|.||..:.||||||...:.|||.:||||:|:|:|.||.:||..::..|.|..::.|
Human   361 FDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLN 425

  Fly   412 DLNADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEI 476
            .:.:..|:..::.::..|||.:.|..::....|:|:.|||.|::|.|:.:|::...|:|:...::
Human   426 TMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDL 490

  Fly   477 PLMRYYRLDSILTFGVRLGCVCGSLIFL 504
            ...:|:.||.|   |..|.||. :.|||
Human   491 TWFQYHSLDVI---GFLLVCVT-TAIFL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	116/491 (24%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	129/531 (24%)