DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	140/530 - (26%)
Similarity:	246/530 - (46%)	Gaps:	68/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKIDGVRHI 75
            |||| |...|...:...:| |||.. .|.:..:|.:::.|..|||:..::.|       :...||
  Rat    12 GLLL-LLYALPWAEGGKVL-VFPME-GSHWLSMRDVVRELHARGHQAVVLAP-------EVTVHI 66

  Fly    76 R-----------VPMLNQ-LMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAILN------NN 122
            :           ||...| ..|.:|:|.:.....|:..:..:..|.|..|:|..:|.      :|
  Rat    67 KEEDFFTLQTYPVPYTRQGFRQQMMRNIKVVFETGNYVKTFLETSEILKNISTVLLRSCMNLLHN 131

  Fly   123 GVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNLAPSVYEPIS 187
            | .:|....|..|||::.:.. :.....||::     |||..:....:|.....:.|....:|.|
  Rat   132 G-SLLQHLNSSSFDMVLTDPV-IPCGAVLAKY-----LGIPTVFFLRYIPCGIDSEATQCPKPSS 189

  Fly   188 --PNGFAL--DN-TFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVI 247
              ||...:  |: |||.|..|.:|....|.:...           .|..|.:...:.|:...|::
  Rat   190 YIPNLLTMLSDHMTFLQRVKNMLYPLALKYICHF-----------SFTRYESLASELLQREVSLV 243

  Fly   248 LVNSHFSMGRVRAN---------VPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYFSMGQ 302
            .|.||.|:...|.:         :||::.:.|:: ....:|...|.:.|:: ..|||.:.||:|.
  Rat   244 EVLSHASVWLFRGDFVFDYPRPVMPNMVFIGGIN-CVIKKPLSQEFEAYVNASGEHGIVVFSLGS 307

  Fly   303 DILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITH 367
              ::..:||....::.....::.|.|:|:...:..:|.::|..::..:||..:|.||..|.||||
  Rat   308 --MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITH 370

  Fly   368 GGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYA 432
            .|...:.|.|.|||||:.:|||.||.:|..|::..|....|:..::.||.|...:|.::.|.||.
  Rat   371 SGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYK 435

  Fly   433 QRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCV 497
            :....:::..:|||:.|||.|::|.||.:|::...|:|....::...:|:.||.|   |..|..|
  Rat   436 ENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFLLAIV 497

  Fly   498 CGSLIFLGWR 507
            . :::|:.::
  Rat   498 L-TVVFIVYK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	124/472 (26%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	134/515 (26%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	74/252 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344043
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790