DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	498	Identity:	131/498 - (26%)
Similarity:	248/498 - (49%)	Gaps:	73/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LIKALVERGHKVTMV--TPADY-PAKIDGVRHIRVP--------MLNQLMQNLMKNDQ------- 92
            |||||..:||.:.::  |.:.| ..|.|....|.:|        .::.::..::.:::
Zfish    46 LIKALHGKGHSIDVIRNTNSWYVKEKSDYYNSITIPQSKGMDEEFVDDMISKVINHERGKSSWLS 110

  Fly    93 ----FFDALGDKWREGVLVSTIFYNVSHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAE 153
                |||::.|.:.    ::.:..:::.:|..:..:...:::|  ::|:::.     |.::|
Zfish   111 TVKLFFDSVIDNYE----MTKMVCDITTSIFESEEILKTLQEK--QYDLMLT-----DPVWG--- 161

  Fly   154 FYNATLLGISCMH-----MTWHIDYLAG-----NLAPS--VYEPISPNGFALDNTFLSRWSNWI- 205
                  :||...|     |.:::.:...     |:|||  .|.||:.:|.....:|..|..|.|
Zfish   162 ------MGIILAHKLKLPMVYNVRWTTTVDGHFNIAPSPMSYIPITGSGNTDRMSFFQRVKNIIF 220

  Fly   206 YITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAG 270
            |.|.:....|... |....:..|:|..|.:....|:.. .:.|:...|.....|..:||||...|
Zfish   221 YFTNDIKYSRFSL-PQYQAICDKYFDPPVDFYQLLQGA-DIWLMRVDFVFEFPRPTMPNIIYTGG 283

  Fly   271 VHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWK--- 331
            ...: |.:|...:|:.::..: :||.|..|:|  ..|..|||::..::...|.::.|:|||:
Zfish   284 FQCT-PAKPLPHDLEDFMQSSGDHGVIVMSLG--TFISALPEDVTAEIAAAFARLPQKVIWRYTG 345

  Fly   332 SELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNI 396
            .:.|.|.|   |..::|.:||:.:|.||..::|:.|||...|.||:.:|||::|:|.||||::|:
Zfish   346 KKPSTLGN---NTLLVDWMPQKDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVGIPFFFDQYDNL 407

  Fly   397 HRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYAL 461
            .|:|..|.||::...:|..::|...|||::.||||....::::....|:|:.|||:||:|.|:.:
Zfish   408 IRLQARGGAKIVSLAELGENSLHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVM 472

  Fly   462 RNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFL 504
            |::..:|:|....::|...|:.:|..:|.      :...|||:
Zfish   473 RHKGAAHLRTESYKMPWYSYHSVDVAVTL------IAVVLIFI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	122/456 (27%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	131/498 (26%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	80/251 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585095
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690