DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt1b1

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001170917.1	Gene:	ugt1b1 / 558508	ZFINID:	ZDB-GENE-080227-10	Length:	528	Species:	Danio rerio

Alignment Length:	563	Identity:	155/563 - (27%)
Similarity:	256/563 - (45%)	Gaps:	104/563 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLGYAW-LAFGLLLHLNLYLELG----QAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMV 60
            ::.|:.| |..||||   |:|..|    |...:| |.|.. .|.:..::.|...|..|||.|.::
Zfish     2 LKKGWLWGLGSGLLL---LWLSAGLRPVQGGRVL-VMPVE-GSHWLSMKVLATELARRGHDVLVL 61

  Fly    61 TP--------------ADYPAKIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVST-- 109
            .|              ..:|.||.         ..||.::|           ..:::||...:
Zfish    62 VPEKNILIQSSELFRTETFPVKIS---------KEQLSKSL-----------KGFQQGVFTRSPA 106

  Fly   110 ---IFYNVSHAILNNNGVQM-----------LMRD-KSIRFDMIMVEASHLDALYGLAEFYN--- 156
               :|..:.. :||..|.|:           |||. |...|::::.:           .|..
Zfish   107 LMDVFVQLER-LLNFTGSQVEGCESLLYNEPLMRKLKEQNFELMLTD-----------PFLPCGP 159

  Fly   157 --ATLLGISCMH----MTWHIDYLAGNL-APSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLE 214
              ||.||:..::    |...||.||... :|..|.|...:|.:....|:.|..|:.....|.:|.
Zfish   160 IIATALGVPAVYFLRGMPCGIDLLASQCPSPPSYVPRFHSGTSDKMNFVERIRNFFMSGFELVLC 224

  Fly   215 RLV---FRPAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEP 276
            :::   |.....|..||...|     .|:..|.::.|....|:....|..:||::.:.|::..:.
Zfish   225 KVMYASFDELAARYLKKDVTY-----KEIIGRGALWLHRYDFTFEYPRPIMPNMVFIGGINCQKS 284

  Fly   277 PEPCGAELQKYLD-EAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANK 340
            .| ..||:::::: ..|||.:.||:|.  |:..:|:.........|..:.|||:|:....:..|.
Zfish   285 AE-ISAEVEEFVNGSGEHGIVVFSLGS--LVSSMPKEKADIFFKAFSMIPQRVLWRYTGEIPDNV 346

  Fly   341 SENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMA 405
            .||:.:|..:||..:|.||..|.||||||...:.|.|..||||:.||||.||.:|:|||...|:.
Zfish   347 PENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICRGVPMVMLPLFGDQADNVHRVATRGVG 411

  Fly   406 KVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMR 470
            .:|..:|:..:||::.:..::.|.||.|:.::::|...|||:.|||.|::|||:.:|::...|:|
Zfish   412 VILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGADHLR 476

  Fly   471 LNVEEIPLMRYYRLDSI-----LTFGVRLGCV-CGSLIFLGWR 507
            ....|:..::|:.||.|     :...|.|..: |.||.   ||
Zfish   477 PAAHELNWLQYHSLDVIGFMLLIVLIVTLAMLKCCSLC---WR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	131/484 (27%)
ugt1b1	NP_001170917.1	UDPGT	29..524	CDD:278624	144/533 (27%)
ugt1b1	NP_001170917.1	egt	<267..507	CDD:223071	82/242 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830