DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and ugt5g2

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001186305.1	Gene:	ugt5g2 / 556049	ZFINID:	ZDB-GENE-081028-66	Length:	534	Species:	Danio rerio

Alignment Length:	538	Identity:	146/538 - (27%)
Similarity:	244/538 - (45%)	Gaps:	73/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLGYAWLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADY 65
            |.|.:.|.:      |.|.|..|..|:.:.|||.. .|.:..:..|:|.|..|||:::::...|
Zfish     5 MSLVFLWTS------LLLSLPSGYNADKILVFPID-GSHWVNMEVLVKKLQSRGHELSVIRLED- 61

  Fly    66 PAKIDGVRHIRVPMLNQLMQNLMKN----DQFFDALG---DKWREGVLVSTI--------FYNVS 115
            ...|.|    ..|..:.:...|.|.    |.|..|:.   |..|:|.::..:        ...|.
Zfish    62 SWFIKG----NSPYYSSITVTLKKKFIDLDLFETAVKKILDARRDGPIMGVLAQMSEFIGILKVG 122

  Fly   116 H--------AILNNN---------GVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGIS 163
            |        ::|.|.         ...:::.|.::...:|:....||..:      ||...:...
Zfish   123 HGANIAMLTSMLENKVLMSQIKMANYDLMLTDPAMPGGVILAHYLHLPMV------YNVRWMSFG 181

  Fly   164 CMHMTWHIDYLAGNLAPS--VYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLF 226
            ..|.         ::|||  .:.|:..:|.......|.|..|:::.....:.||.:..|....|.
Zfish   182 EGHF---------SIAPSPISFVPVPGSGLTDRMGLLERSRNFLHYGLNLIQERWMVIPMYTSLL 237

  Fly   227 KKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA 291
            ...|. |...|..::....:.||.:.|.....|.::||::.:.|.. ..|.:|..|:|::::..:
Zfish   238 LNHFP-PGTDLLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQ-CRPAKPLPADLEEFMQSS 300

  Fly   292 -EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWK---SELSMLANKSENIYVMDKVPQ 352
             :||.:..|:|  .||..||:.:.:.:...|.|:.|:|||:   ...|.|.|   |..::..:||
Zfish   301 GDHGVVVMSLG--TLIAGLPKEVMEAIASAFAQIPQKVIWRFIGQRPSTLGN---NTLLIQWLPQ 360

  Fly   353 RMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADT 417
            ..:|.||..|.|:.|||...:.|||.:|||:|||||.|||.:||.|:|..|.|::||....:...
Zfish   361 NDLLGHPKTRAFVAHGGTNGLYEAIYHGVPVLGLPLLFDQLDNIVRLQARGGARMLDAATCSTKE 425

  Fly   418 LIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYY 482
            .:..:.::||||:|.|..::::...||||:.|||.|::|.|:.|||:...|:|.....:....||
Zfish   426 FLVALTDILENPTYRQNMQKLSNLHRDRPLHPLDKAVYWIEFVLRNKGAPHLRAEAYNVSEFSYY 490

  Fly   483 RLDSI-LTFGVRLGCVCG 499
            .||.: |...:.||.:.|
Zfish   491 CLDVVALVLFMLLGTLGG 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	128/477 (27%)
ugt5g2	NP_001186305.1	egt	3..507	CDD:223071	145/535 (27%)
ugt5g2	NP_001186305.1	UDPGT	25..513	CDD:278624	138/512 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584632
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690