DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	563	Identity:	152/563 - (26%)
Similarity:	245/563 - (43%)	Gaps:	114/563 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPA---------------------K 68
            |.|:| |.|... |.:|.:|.::..|:.|.|.||::..:..|.                     :
Zfish    22 AGNVL-VLPGEY-SHWQNMRNVVDELLNRNHTVTVLVCSASPTINFTQQERFQYLVFEVPLSAQE 84

  Fly    69 IDGVR----HI--RVPMLNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAILNNNGVQML 127
            :||..    ||  :.|..|:|...|    |..:.||.            ..|.|         ..
Zfish    85 LDGASEELIHIWTQHPSPNRLQTAL----QIIELLGR------------VRVMH---------RA 124

  Fly   128 MRDKSIRFDMIMVEASHL--DALYGLAEFYNATLLGISCMHMTWHIDYLAGNLAPSVYEPISPNG 190
            |.|..:|.|.::.:.|.|  |.|:....|..|.||.          :.|...|..||  .||| |
Zfish   125 MCDSMLRNDALIAQLSALKFDVLFNDPMFMCADLLA----------EMLGLPLVLSV--RISP-G 176

  Fly   191 FALDNTF--LSRWSNWIYITEEKLLERLVFRP------AQVRLFKKFF---------------GY 232
            |.|:...  :....:::.||:..|.:|:.|..      |.:.....|:               |.
Zfish   177 FCLERMCGQMPAPPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVAWISLDSYYTDVLGK 241

  Fly   233 PAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAI 296
            |. .:.|...:..:.|:.:::.....|...||...|.|:| .:|.:|...|:::::..: :||.:
Zfish   242 PT-TMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLH-CKPAKPLSKEMEEFVQSSGDHGVV 304

  Fly   297 YFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNL 361
            .||:|.  :||.|.......:.....|:.|:|:|:.........:.|..:.|.:||..:|.||..
Zfish   305 VFSLGS--MIKNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKT 367

  Fly   362 RLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELL 426
            :.||||||...:.|||.:||||:|||||.||.:|:..::..|.|.|||.|.|.:..|::.:|.:|
Zfish   368 KAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVL 432

  Fly   427 ENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLD------ 485
            .||||.:....::....|:||.|||.|::|.|:.:||:...|:|:...|:...:|:.||
Zfish   433 NNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLL 497

  Fly   486 ---SILTF-GVRLGCVCGSLIFLGWRLYQKNR-NRHTRLQERE 523
               :::|| .|:..|      ||..|..:|.| .|.|:..:.|
Zfish   498 SIAALITFLWVKACC------FLFRRCVRKTRPERKTQKSKNE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	133/491 (27%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	146/547 (27%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	78/233 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860