DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt2a2

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001019319.1	Gene:	Ugt2a2 / 552899	MGIID:	3576095	Length:	528	Species:	Mus musculus

Alignment Length:	542	Identity:	130/542 - (23%)
Similarity:	254/542 - (46%)	Gaps:	92/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPAD---YPAKIDG-V 72
            |:.||.| .|:..:.|:: |:| ...|.:..::.|::.||:|.|.||::.|::   ..:::|. :
Mouse     9 LIFHLTL-AEIVLSGNVV-VWP-TDGSHWLNIKILLEELVQRNHSVTVLAPSETLFINSRLDAFI 70

  Fly    73 RHIRVPM------LNQLMQNL-----------MKNDQFFDALGDKWREGVLVSTIFYNVS----H 116
            ....:|:      ::::::::           :....|:..||:      |::| ||..:    .
Mouse    71 NFEEIPVSYTKSKIDEIIEHMIALWLDHRPTPLTMWTFYKELGN------LLAT-FYTTNKQMCD 128

  Fly   117 AILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHM-----TWHIDYLAG 176
            .:|||..|  :.|.:...||:::.     |.:....|.. |..|||..::.     .:.::...|
Mouse   129 GVLNNPTV--MERLQKGGFDVLLA-----DPVTMCGELV-ALKLGIPFVYTLRFSPAFTVERHCG 185

  Fly   177 NL-APSVYEPISPN----------------GFAL-DNTFLSRWSNWIYITEEKLLERLVFRPAQV 223
            .: ||..|.|.:.:                .::| |..|.:.|..|                  .
Mouse   186 KIPAPISYVPAALSELTDQMSFGERVKNIISYSLQDYIFKTYWGEW------------------N 232

  Fly   224 RLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYL 288
            ..:.|..|.|. .|.|...:..:.|:.:::.....|..:||...|.|:| .:|.:|...|:::::
Mouse   233 SYYSKVLGRPT-TLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLH-CKPAKPLPKEMEEFV 295

  Fly   289 D-EAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQ 352
            . ..|||.:.||:|.  ::|.|.:.....:.....|:.|:|:|:.:..:......|..:.|.:||
Mouse   296 QTSGEHGIVVFSLGS--MVKNLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLFDWIPQ 358

  Fly   353 RMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADT 417
            ..:|.||..|.||||||...:.|||.:|:||:|:|:|.||.:||..::..|.|..::.|.:.:..
Mouse   359 NDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSD 423

  Fly   418 LIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYY 482
            |:..::.::..|||.:.|..::....|:|:.|||.|::|.|:.:|::...|:|:...::...:|:
Mouse   424 LLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYH 488

  Fly   483 RLDSILTFGVRLGCVCGSLIFL 504
            .||.|   |..|.||..:::.:
Mouse   489 SLDVI---GFLLACVASAILLV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	115/488 (24%)
Ugt2a2	NP_001019319.1	UDPGT	22..516	CDD:278624	125/528 (24%)
Ugt2a2	NP_001019319.1	egt	<267..487	CDD:223071	67/222 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840202
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790