Protein Alignment Ugt303B2 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 137/555 - (24%)
• Similarity: 252/555 - (45%)
• Gaps: 74/555 - (13%)

  Fly     8 LAFGLLLHLNLYLELGQAANILGVFPYRIP---SPFQMVRPLIKALVERGHKVTMVTPADYPAKI 69
            |..||||.:     ||...:..|.. ..||   |.:..:...|:.|.:|||::.::.|
Human    11 LVLGLLLCV-----LGPVVSHAGKI-LLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAP------- 62

  Fly    70 DGVRHIR-----------VPMLNQ--------LMQNLMKNDQFFDALGDKWRE-----GVLVSTI 110
            |...:||           ||...:        |..|:.:||.|...:...:::     .:|:|
Human    63 DASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLS-- 125

  Fly   111 FYNVSHAILNNNGVQMLMRDKSIRFDMIMVE----ASHLDALYGLAEFYNATLLGISCMH-MTWH 170
              ..|| :|:|..:...:.:.|  ||:::.:    .|.:.|.|       .:|..:..:| :...
Human   126 --GCSH-LLHNKELMASLAESS--FDVMLTDPFLPCSPIVAQY-------LSLPTVFFLHALPCS 178

  Fly   171 IDYLAGNLA-PSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPA 234
            :::.|.... |..|.|...:..:...|||.|..|.:....:..|..:|:.| ...|..:|.....
Human   179 LEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSP-YATLASEFLQREV 242

  Fly   235 EKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYF 298
             .:.:|.:..||.|..|.|.....|..:||::.|.|::... ..|...|.:.|:: ..|||.:.|
Human   243 -TVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLH-QNPLSQEFEAYINASGEHGIVVF 305

  Fly   299 SMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRL 363
            |:|.  ::..:||.....:.....::.|.|:|:...:..:|.:.|..::..:||..:|.||..|.
Human   306 SLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRA 368

  Fly   364 FITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLEN 428
            ||||.|...|.|:|.|||||:.:|||.||.:|..|::..|....|:..::.::.|...:|.::.:
Human   369 FITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIND 433

  Fly   429 PSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVR 493
            .||.:....:::..:|||:.|||.|::|.|:.:|::...|:|....::...:|:.||.|   |..
Human   434 KSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFL 495

  Fly   494 LGCVCGSLIFLGWRL----YQKNRNRHTRLQERER 524
            |..|. ::.|:.::.    |:|...:..|:::..:
Human   496 LAVVL-TVAFITFKCCAYGYRKCLGKKGRVKKAHK 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	117/473 (25%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	129/526 (25%)