Protein Alignment Ugt303B2 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 131/509 - (25%)
• Similarity: 247/509 - (48%)
• Gaps: 50/509 - (9%)

  Fly    43 VRPLIKALVERGHKVTMVTPA---DYPAKIDGVRHIRVPMLNQLMQNLMKNDQFFDALGD-KWRE 103
            :|.:::.|:.|||:|.:|.|.   .....::..  ::....:..:::|   |:.|.|... :|:.
Human    41 MRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCT--VKTYSTSYTLEDL---DREFKAFAHAQWKA 100

  Fly   104 GV--LVSTIF--YNVSHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLL---- 160
            .|  :.|.:.  ||....:..:| .:.|.:||.:   :..::.|..||:: |..|.|..|:
Human   101 QVRSIYSLLMGSYNDIFDLFFSN-CRSLFKDKKL---VEYLKESSFDAVF-LDPFDNCGLIVAKY 160

  Fly   161 ----------GISCMHMTWHIDYLAGNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLER 215
                      ||.| |   :::..|...||..|.|....||:...||..|..|.|...||.||..
Human   161 FSLPSVVFARGILC-H---YLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCH 221

  Fly   216 LVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPC 280
            ..|:.| :.:..:....|..:.| |.:..|:.|:.:.|.:...:..:||:|.:.|::..: .:|.
Human   222 RFFKNA-LEIASEILQTPVTEYD-LYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQ-GKPL 283

  Fly   281 GAELQKYLD-EAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENI 344
            ..|.:.|:: ..|||.:.||:|.  ::..:||.....:.....::.|.|:|:...:..:|.:.|.
Human   284 PMEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNT 346

  Fly   345 YVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLD 409
            .::..:||..:|.||..|.||||.|...|.|:|.|||||:.:|||.||.:|..|::..|....|:
Human   347 ILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLN 411

  Fly   410 PNDLNADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVE 474
            ..::.::.|...:|.::.:.||.:....:::..:|||:.|||.|::|.|:.:|::...|:|....
Human   412 VLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH 476

  Fly   475 EIPLMRYYRLDSILTFGVRLGCVCGSLIFLGWRL----YQKNRNRHTRLQERER 524
            ::...:|:.||.|   |..|..|. ::.|:.::.    |:|...:..|:::..:
Human   477 DLTWYQYHSLDVI---GFLLAVVL-TVAFITFKCCAYGYRKCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	118/443 (27%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	130/502 (26%)