Protein Alignment Ugt303B2 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 147/561 - (26%)
• Similarity: 258/561 - (45%)
• Gaps: 86/561 - (15%)

  Fly     8 LAFGLLLHLNL--YLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKID 70
            ||.||||.|::  :.|.|:..    |.| ...|.:..:|..::.|..|||:|.::|
Human    12 LATGLLLLLSVQPWAESGKVL----VVP-TDGSHWLSMREALRDLHARGHQVVVLT--------- 62

  Fly    71 GVRHIRVPMLNQLMQNLMKNDQFFD----ALG---DKWREGVLVST-IFYNVSH---------AI 118
                :.|.|       .:|.:.||.    |:.   |::...:|..| .|:...|         ||
Human    63 ----LEVNM-------YIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAI 116

  Fly   119 LNN-------NGVQMLMRDKSIR------FDMIMVEASHLDALYGLAEFYNAT----LLGISCMH 166
            :||       :.|::|..:..||      ||:::.:..||.|.. ||::.:..    |..|.|
Human   117 MNNMSLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAV-LAKYLSIPAVFFLRNIPC-- 178

  Fly   167 MTWHIDYLAGNLA-PSVYEP--ISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKK 228
               .:|:...... ||.|.|  ::.|...:  |||.|..|.:|......|...|..| ...|..:
Human   179 ---DLDFKGTQCPNPSSYIPRLLTTNSDHM--TFLQRVKNMLYPLALSYLCHAVSAP-YASLASE 237

  Fly   229 FFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAE 292
            .|......:| |.:..||.|....|.|...|..:||::.:.|::.:. .:|...|.:.|:: ..|
Human   238 LFQREVSVVD-LVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCAN-GKPLSQEFEAYINASGE 300

  Fly   293 HGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLA 357
            ||.:.||:|.  ::..:||.....:.....::.|.|:|:...:..:|.:.|..::..:||..:|.
Human   301 HGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLG 363

  Fly   358 HPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETI 422
            ||..|.||||.|...|.|:|.|||||:.:|||.||.:|..|::..|....|:..::.::.|...:
Human   364 HPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENAL 428

  Fly   423 KELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSI 487
            |.::.:.||.:....:::..:|||:.|||.|::|.|:.:|::...|:|....::...:|:.||.|
Human   429 KAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVI 493

  Fly   488 LTFGVRLGCVCGSLIFLGWRL----YQKNRNRHTRLQERER 524
               |..|..|. ::.|:.::.    |:|...:..|:::..:
Human   494 ---GFLLAVVL-TVAFITFKCCAYGYRKCLGKKGRVKKAHK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	125/477 (26%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	138/537 (26%)
		egt	<262..508	CDD:223071	73/252 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150589
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.790