Protein Alignment Ugt303B2 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 129/537 - (24%)
• Similarity: 242/537 - (45%)
• Gaps: 105/537 - (19%)

  Fly    43 VRPLIKALVERGHKVTMVTP---------ADYPAKIDGVRHIRVPMLNQLM---QNLMKNDQFFD 95
            ::.:::.|.:|||::.:|.|         ..|..||..|.:.:..:.|:..   .|......|..
Human    42 MKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLT 106

  Fly    96 ALGDKWREGVLVSTIFYNVSHAILNNNGVQMLMRDK-SIRFDMIMVEASHLDALYG--------- 150
            |...::|..::|..:::      :|   .|.|::|: ::.|    .:.|..|||:.
Human   107 APQTEYRNNMIVIGLYF------IN---CQSLLQDRDTLNF----FKESKFDALFTDPALPCGVI 158

  Fly   151 LAEFYNATLLGISCMHMTWHIDYLAGNLAPSVY-----------------EPIS--P---NGFAL 193
            |||:     ||:                 ||||                 :|:|  |   ..|:.
Human   159 LAEY-----LGL-----------------PSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSD 201

  Fly   194 DNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDE------LRARFSVILVNSH 252
            ..||..|.:|::.    .|||..:|    ..||.|:....:..|..      |..:.||.|:...
Human   202 HMTFSQRVANFLV----NLLEPYLF----YCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYD 258

  Fly   253 FSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYFSMGQDILIKYLPENMQKQ 316
            |.:...|..:||::.:.|::..:..: ...|.:.|:: ..|||.:.||:|.  ::..:||.....
Human   259 FVLEYPRPVMPNMVFIGGINCKKRKD-LSQEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMA 320

  Fly   317 LLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGV 381
            :.....::.|.|:|:...:..:|.:.|..::..:||..:|.||..|.||||.|...|.|:|.|||
Human   321 IADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGV 385

  Fly   382 PMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDRP 446
            ||:.:|||.||.:|..|::..|....|:..::.::.|...:|.::.:.||.:....:::..:|||
Human   386 PMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRP 450

  Fly   447 MSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFLGWRL--- 508
            :.|||.|::|.|:.:|::...|:|....::...:|:.||.|   |..|..|. ::.|:.::.
Human   451 VEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFLLAVVL-TVAFITFKCCAY 511

  Fly   509 -YQKNRNRHTRLQERER 524
             |:|...:..|:::..:
Human   512 GYRKCLGKKGRVKKAHK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	116/471 (25%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	126/513 (25%)
		UDPGT	27..523	CDD:278624	128/530 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150649
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690