Protein Alignment Ugt303B2 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 144/555 - (25%)
• Similarity: 263/555 - (47%)
• Gaps: 63/555 - (11%)

  Fly     2 RLGYAWLAFGLL-LHLNLYLELGQA-ANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPAD 64
            |.|:.    ||| |::.|.|..|.| |..|.|.|......|.| :.:::.|:.|||:|.:|.| :
Human     3 RAGWT----GLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTM-QSVVEKLILRGHEVVVVMP-E 61

  Fly    65 YPAKIDGVRHIRVPMLNQLMQNLMKNDQFFDALGD-KWRE------GVLVST------IFYNVSH 116
            ...::....:..|...: ....|...|:.|....| :|..      .:|.|:      :|::...
Human    62 VSWQLGRSLNCTVKTYS-TSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCR 125

  Fly   117 AILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGL--AEFYNATLL----GISCMHMTWHIDYLA 175
            ::.|:..:...:::..  ||.:.::.  .||. ||  |::::...:    ||.| |   :::..|
Human   126 SLFNDRKLVEYLKESC--FDAVFLDP--FDAC-GLIVAKYFSLPSVVFARGIFC-H---YLEEGA 181

  Fly   176 GNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLD-- 238
            ...||..|.|....||:...||..|..|.|...||.|     |.|   ..||......:|.|.
Human   182 QCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHL-----FCP---YFFKNVLEIASEILQTP 238

  Fly   239 ----ELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYF 298
                :|.:..|:.|:.:.|.:...:..:||:|.:.|::..: .:|...|.:.|:: ..|||.:.|
Human   239 VTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQ-GKPVPMEFEAYINASGEHGIVVF 302

  Fly   299 SMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRL 363
            |:|.  ::..:||.....:.....::.|.|:|:...:..:|.:.|..::..:||..:|.||..|.
Human   303 SLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRA 365

  Fly   364 FITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLEN 428
            ||||.|...|.|:|.|||||:.:|||.||.:|..|::..|....|:..::.::.|...:|.::.:
Human   366 FITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIND 430

  Fly   429 PSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVR 493
            .||.:....:::..:|||:.|||.|::|.|:.:|::...|:|....::...:|:.||.|   |..
Human   431 KSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFL 492

  Fly   494 LGCVCGSLIFLGWRL----YQKNRNRHTRLQERER 524
            |..|. ::.|:.::.    |:|...:..|:::..:
Human   493 LAVVL-TVAFITFKCCAYGYRKCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	122/466 (26%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	132/521 (25%)