Protein Alignment Ugt303B2 and UGT1A8

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 136/538 - (25%)
• Similarity: 260/538 - (48%)
• Gaps: 50/538 - (9%)

  Fly    14 LHLNLYLELGQA-ANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPA---DYPAKIDGVRH 74
            |.::|.|..|.| |..|.|.|......|.| :.:::.|:.|||:|.:|.|.   .....::..
Human    12 LCVSLLLTCGFAEAGKLLVVPMDGSHWFTM-QSVVEKLILRGHEVVVVMPEVSWQLGKSLNCT-- 73

  Fly    75 IRVPMLNQLMQNLMKNDQFFDALGDKWREGV--LVS----------TIFYNVSHAILNNNGVQML 127
            ::....:..:::|  :.:|.|....:|:..|  |.|          .:|::...::.|:..:...
Human    74 VKTYSTSYTLEDL--DREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEY 136

  Fly   128 MRDKSIRFDMIMVEASHLDALYGL--AEFYNATLL----GISCMHMTWHIDYLAGNLAPSVYEPI 186
            :::.|  ||.:.::.  .||. ||  |::::...:    ||:| |   :::..|...||..|.|.
Human   137 LKESS--FDAVFLDP--FDAC-GLIVAKYFSLPSVVFARGIAC-H---YLEEGAQCPAPLSYVPR 192

  Fly   187 SPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNS 251
            ...||:...||..|..|.|...||.|..: .|....:.:..:....|....| |.:..|:.|:.:
Human   193 ILLGFSDAMTFKERVRNHIMHLEEHLFCQ-YFSKNALEIASEILQTPVTAYD-LYSHTSIWLLRT 255

  Fly   252 HFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYFSMGQDILIKYLPENMQK 315
            .|.:...:..:||:|.:.|::..: .:|...|.:.|:: ..|||.:.||:|.  ::..:||....
Human   256 DFVLDYPKPVMPNMIFIGGINCHQ-GKPLPMEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAM 317

  Fly   316 QLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNG 380
            .:.....::.|.|:|:...:..:|.:.|..::..:||..:|.||..|.||||.|...|.|:|.||
Human   318 AIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNG 382

  Fly   381 VPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDR 445
            |||:.:|||.||.:|..|::..|....|:..::.::.|...:|.::.:.||.:....:::..:||
Human   383 VPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDR 447

  Fly   446 PMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFLGWRL-- 508
            |:.|||.|::|.|:.:|::...|:|....::...:|:.||.|   |..|..|. ::.|:.::.
Human   448 PVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFLLAVVL-TVAFITFKCCA 508

  Fly   509 --YQKNRNRHTRLQERER 524
              |:|...:..|:::..:
Human   509 YGYRKCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	119/462 (26%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	129/517 (25%)