Protein Alignment Ugt303B2 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 123/503 - (24%)
• Similarity: 248/503 - (49%)
• Gaps: 38/503 - (7%)

  Fly    43 VRPLIKALVERGHKVTMVTPADYPAKIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDKWRE---- 103
            ::.:::.|:.|||:|.:|.| :...:::...:..|...:.......:|.:|......:|:.
Human    41 MQSVVEKLILRGHEVVVVMP-EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQS 104

  Fly   104 --GVLVST------IFYNVSHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLL 160
              .:|:|:      :|::...::.|:..:...:::.|  ||.:.::......|. :|::::...:
Human   105 IFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESS--FDAVFLDPFDTCGLI-VAKYFSLPSV 166

  Fly   161 ----GISCMHMTWHIDYLAGNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPA 221
                ||.| |   |::..|...||..|.|....||:...||..|..|.|...|:.|..:.:||.|
Human   167 VFTRGIFC-H---HLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNA 227

  Fly   222 QVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQK 286
             :.:..:....|....| |.:..|:.|:.:.|.:...:..:||:|.:.|::..: .:|...|.:.
Human   228 -LEIASEILQTPVTAYD-LYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQ-GKPLPMEFEA 289

  Fly   287 YLD-EAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKV 350
            |:: ..|||.:.||:|.  ::..:||.....:.....::.|.|:|:...:..:|.:.|..::..:
Human   290 YINASGEHGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWL 352

  Fly   351 PQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNA 415
            ||..:|.||..|.||||.|...|.|:|.|||||:.:|||.||.:|..|::..|....|:..::.:
Human   353 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS 417

  Fly   416 DTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMR 480
            :.|...:|.::.:.||.:....:::..:|||:.|||.|::|.|:.:|::...|:|....::...:
Human   418 EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQ 482

  Fly   481 YYRLDSILTFGVRLGCVCGSLIFLGWRL----YQKNRNRHTRLQERER 524
            |:.||.|   |..|..|. ::.|:.::.    |:|...:..|:::..:
Human   483 YHSLDVI---GFLLAVVL-TVAFITFKCCAYGYRKCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	110/437 (25%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	122/496 (25%)