DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and Ugt8

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	154/558 - (27%)
Similarity:	266/558 - (47%)	Gaps:	73/558 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKIDG 71
            |.|.|          :.:||.|:.|.|....|...:.:.|..||.||||....:....  ..||.
  Rat    12 WSAVG----------IARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLSEG--RDIDP 64

  Fly    72 VRHI---RVPML------NQLMQNLMKN--------DQFFDALGDKWREGVLVSTIFYNVSHAIL 119
            ..|.   |.|.:      :..:|:.|:|        .:..|.| |.:.:         |....:.
  Rat    65 SNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDIL-DHYTK---------NCDMMVG 119

  Fly   120 NNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLA--GNLAPSV 182
            |...:|.|.::|   ||:::|:.:      .:..|..|.|||:.....:..:.|.|  |..||..
  Rat   120 NQALIQGLKKEK---FDLLLVDPN------DMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLA 175

  Fly   183 YEPISPNGFALDN-TFLSRWSN-WIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFS 245
            |.| ..|....|. .||.|..| .:|:.....:..||. |...|:.:|:...||:.:.:|....|
  Rat   176 YVP-EFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVL-PKYERIMQKYNLLPAKSMYDLVHGSS 238

  Fly   246 VILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYL 309
            :.::.:..::...|..:||::.|.|: |::|..|...:||:::|.| |||.:..|.|..  :|||
  Rat   239 LWMLCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVDGAQEHGFVLVSFGAG--VKYL 300

  Fly   310 PENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVM 374
            .|::..:|.....::.|:|||:...:...|...|..:::.:||..:|.|.|:|.|::||||.|:.
  Rat   301 SEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIF 365

  Fly   375 EAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMA 439
            |.:.:|||::|:|||.|.::.:.|||..||..:|:.|.:....|.:.:.:::.||||.|||::::
  Rat   366 ETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLS 430

  Fly   440 ASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLI-- 502
            ...:|:|..|::...:|.:|.||:....|:|..|.:|...:|:.||  :.|.:.||.|....|
  Rat   431 EIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLD--IAFVLLLGAVALYFIVS 493

  Fly   503 FLGWRLYQK-----NRNRHTRLQERERVIAQIQLGLSN 535
            ::...:|:|     :|:.|:      .|....|.|:.|
  Rat   494 YVTKFIYRKVKSLCSRSTHS------TVNGHYQNGILN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	131/461 (28%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	145/515 (28%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	143/508 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344187
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.740