DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	133/531 - (25%)
Similarity:	240/531 - (45%)	Gaps:	69/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPA------------- 63
            |||||.::...|....:| |:|... |.:..::.::..||::||:|.::.|:
  Rat    10 LLLHLTIFFGSGSGGKVL-VWPVEF-SHWLNLKIILSELVKKGHEVVVLKPSVSFSYEVDKTSAI 72

  Fly    64 ---DYPA--KIDGVRHIRVPMLNQLMQNLMKN---------DQFFDALGDKWREGVLVSTIFYNV 114
               .:|:  .|..|..|.:..:|:.:..|.|.         .:.|:...| :.|.:.....|...
  Rat    73 EFESFPSSYSIADVEVIFMDCVNESIYELPKQSFWGYFLMLQKLFERTSD-YSERLCRDAAFNKE 136

  Fly   115 SHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNLA 179
            ....|.|:|..:::.|.......::.|...:..:|.|..|..:|           :..|..|...
  Rat   137 LMTKLQNSGFDVILADPFTPCGDLLAEILKIPLVYSLRFFPGST-----------YEKYSGGLPM 190

  Fly   180 PSVYEPISPNGFALDNTFLSRWSNWIYI----------TEEKLLERLVFRPAQVRLFKKFFGYPA 234
            |..|.||:.:..:...||:.|..:.||:          .|:|..|          |:.:..|.|.
  Rat   191 PPSYVPIAMSELSDRMTFVERVKHMIYVLCFDFWFQVFDEKKWNE----------LYTEVLGRPT 245

  Fly   235 EKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYF 298
             .|.|..|:..:.|:.:::.:......:||...|.|:| ..|.:|...|::.::..: |||.:.|
  Rat   246 -TLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLH-CRPAKPLPKEIEDFVQSSGEHGVVVF 308

  Fly   299 SMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRL 363
            |:|.  ::..|.|.....:.....|:.|:|:|:.|.........|..:...:||..:|.||..|.
  Rat   309 SLGS--MVGSLTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDLLGHPKTRA 371

  Fly   364 FITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLEN 428
            ||||||...:.|||.:|:|::|:|||.||.:||..::..|.|..||...:::..|:..::.:..:
  Rat   372 FITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTMSSTDLLTALRTVTND 436

  Fly   429 PSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVR 493
            |||.:.|..::....|:|:.|||.|::|.|:.:|::...|:|:...::..::|:.||.|   |..
  Rat   437 PSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSWVQYHSLDVI---GFL 498

  Fly   494 LGCVCGSLIFL 504
            |.||...:..|
  Rat   499 LACVVTVMFIL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	116/477 (24%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	127/517 (25%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	75/243 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344085
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.690