DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	172/505 - (34%)
Similarity:	278/505 - (55%)	Gaps:	11/505 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GYAWLAFGLLLHLNLYLELG-QAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPA 67
            |...|..||:.......:.| |::.||.|||:...|.:......:|.|..|||.||::.......
  Fly     9 GLGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDK 73

  Fly    68 KIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYN-VSHAILNNNGVQMLMRDK 131
            .....|.|....::::|......|  :.....:| :.:.::|.|.| ::.:||::..|:.|: :.
  Fly    74 NEPNFRVIGAKKIHEIMAAFGNAD--YTQTASQW-QMLTMTTQFLNLLTTSILDDAAVKDLL-NS 134

  Fly   132 SIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNLAPSVYEPISPNGFALDNT 196
            ..:||::::||...:||:||.:.:.|..:|||......|||.|.||::|..|.|:..:.......
  Fly   135 GEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMD 199

  Fly   197 FLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRAN 261
            |..|..|....:...|.:|:|..|:|..|:.|:|....:.|||:...|:::|:..|||:...|..
  Fly   200 FKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPY 264

  Fly   262 VPNIIEVAGVHLSE--PPEPCGAELQKYLDEAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQM 324
            :||:|||.|:||.:  ..:|...||.::::::|.|.||||||.:|..|.||.:.:|.|:..|..:
  Fly   265 LPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASV 329

  Fly   325 KQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLF 389
            .|||:||.|...|..|.:|:::....||..:|||||::||||||||.|.:|:|..|.|:||||:|
  Fly   330 PQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIF 394

  Fly   390 FDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAI 454
            :||..|:.|.:..|.....|...:||..|...|:|||.|||||..|:..:..|||:..:.|:.||
  Fly   395 YDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAI 459

  Fly   455 WWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFL 504
            |||||.||::...|:|....::..::::.||   |:|:.:.....||:.:
  Fly   460 WWTEYVLRHKGAKHLRCASRDLDFIQFHGLD---TWGLLIAITFVSLLIV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	159/442 (36%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	160/458 (35%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	159/459 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445579
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800