DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt1a9

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_964006.2	Gene:	Ugt1a9 / 394434	MGIID:	3576092	Length:	528	Species:	Mus musculus

Alignment Length:	530	Identity:	139/530 - (26%)
Similarity:	242/530 - (45%)	Gaps:	66/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAFGLLLHLNLYLE--LGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKID 70
            :||.....|.|.|.  |.||..:| |.|......|.| :.:::.|:.|||:|.:|.|
Mouse     4 VAFPTSFFLCLLLASGLAQAGRLL-VVPMDGSHWFTM-QMVVEKLIHRGHEVVVVIP-------- 58

  Fly    71 GVRHIRVP-MLNQLMQNLMKNDQFFDALGDKWREGVLVS-TIFYNVSHAI-------------LN 120
                 .|. .|.:.:...:|.......|.|..||...:| |.:....|:|             |.
Mouse    59 -----EVSWQLGKSLNCTVKTYSISHTLEDLDREFKYLSYTQWKTPEHSIRSFLTGSARGFFELT 118

  Fly   121 NNGVQMLMRDKSI-------RFDMIMVEASHLDALYGLAEFYNATLL----GISCMHMTWHIDYL 174
            .:..:.|..||.:       .||.:.::...:..|. :|::::...:    |:.|       |||
Mouse   119 FSHCRSLFNDKKLVEYLKQRFFDAVFLDPFDVCGLI-VAKYFSLPSVIFARGVFC-------DYL 175

  Fly   175 -AGNLAPSV--YEPISPNGFALDNTFLSR-WSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAE 235
             .|...||:  |.|...:.:....||..| |::.|||.|.....  .|....|.:..:....|..
Mouse   176 EEGAQCPSLPSYVPRLFSKYTDTMTFKERVWNHLIYIEEHAFCS--YFLRTAVEVASEILQTPVT 238

  Fly   236 KLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYFS 299
            ..| |.:..|:.|:.:.|.:...|..:||::.:.|::..: .:....|.:.|:: ..|||.:.||
Mouse   239 MTD-LFSPVSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQ-KKSLSKEFEAYVNASGEHGIVVFS 301

  Fly   300 MGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLF 364
            :|.  ::..:||....::.....::.|.|:|:...:..:|.::|..::..:||..:|.||..|.|
Mouse   302 LGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAF 364

  Fly   365 ITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENP 429
            |||.|...:.|.|.|||||:.:|||.||.:|..|::..|....|:..::.||.|...:|.::.|.
Mouse   365 ITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNK 429

  Fly   430 SYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRL 494
            ||.:....:::..:|||:.|||.|::|.||.:|::...|:|....::...:|:.||.|   |..|
Mouse   430 SYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFLL 491

  Fly   495 GCVCGSLIFL 504
            ..|. :::|:
Mouse   492 AIVL-TVVFI 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	123/470 (26%)
Ugt1a9	NP_964006.2	egt	9..500	CDD:223071	136/523 (26%)
Ugt1a9	NP_964006.2	UDPGT	24..519	CDD:278624	131/510 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840346
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690