DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_964005.2	Gene:	Ugt1a5 / 394433	MGIID:	3032634	Length:	529	Species:	Mus musculus

Alignment Length:	519	Identity:	138/519 - (26%)
Similarity:	242/519 - (46%)	Gaps:	54/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPA---------DYP 66
            ||||...|....|:  .:| |||.. .|.:..:|.:::.|..:||:..::.|.         .:.
Mouse    12 GLLLLCALPWTEGE--KVL-VFPVG-GSHWLSMRDVVRELHAQGHQTVVLAPEVNMRIKEEDFFT 72

  Fly    67 AKIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAILNN-----NGVQM 126
            .|:     ..||...|.::.:|:|.:.|...|:..::....|....|:|..:|..     :...:
Mouse    73 FKV-----YAVPYTRQELEEMMENLKVFFDTGNYMKKIFKTSEALRNMSTVLLKTCTNILHNESL 132

  Fly   127 LMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCM----HMTWHIDYLAGNL-APSVYEPI 186
            |....|..||::..     |.::...... |..|||..:    ::...|:|.|... :||.|
Mouse   133 LHHLNSSSFDVVFT-----DPVFPCGALL-AKYLGIPAVFFLRYIPCGIEYEATQCPSPSSY--- 188

  Fly   187 SPNGFA-----LDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSV 246
            .||.|.     :|  ||.|..|.:|....|.:..|:..|.: .|..:.|......: ||.:..||
Mouse   189 IPNLFTRLSDHMD--FLQRVQNMLYHLVLKYICHLLITPYE-SLASELFQREVSSV-ELFSYASV 249

  Fly   247 ILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYFSMGQDILIKYLP 310
            .|....|.:...|..:||::.:.|:: ....:|...|.:.|:: ..|||.:.||:|.  ::..:|
Mouse   250 WLFRGDFVLDYPRPIMPNMVFIGGIN-CVTKKPLSQEFEAYVNASGEHGIVVFSLGS--MVSEIP 311

  Fly   311 ENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVME 375
            |....::.....::.|.|:|:...:..:|.::|..::..:||..:|.||..|.||||.|...:.|
Mouse   312 EKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYE 376

  Fly   376 AIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAA 440
            .|.|||||:.:|||.||.:|..|::..|....|:..::.||.|...:|.::.|.||.:....:::
Mouse   377 GICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSS 441

  Fly   441 SFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFL 504
            ..:|||:.|||.|::|.||.:|::...|:|....::...:|:.||.|   |..|..|. :::|:
Mouse   442 LHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFLLAIVL-TVVFI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	122/464 (26%)
Ugt1a5	NP_964005.2	UDPGT	26..520	CDD:278624	132/503 (26%)
Ugt1a5	NP_964005.2	egt	<257..501	CDD:223071	74/250 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840629
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.690