DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	135/559 - (24%)
Similarity:	251/559 - (44%)	Gaps:	87/559 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADY----PA 67
            |::..|||.::...:.|....:| |:|... |.:..::.::..||:|||:||::.|:.|    |.
  Rat     5 WISALLLLQISCCFQSGNCGKVL-VWPMEF-SHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPK 67

  Fly    68 KIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDKW-----REGVL------------VSTIFYNVS 115
            |...::....|  ..:.::.::|  :|..|.|.|     |:..|            .|..:.::.
  Rat    68 KSPDLKFETFP--TSVSKDELEN--YFIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDYYLSLC 128

  Fly   116 HAILNNNGVQMLMRDKSIRFDMIM-----------VEASHLDALYGLAEFYNATLLGISCMHMTW 169
            ...::|.  |::.:.:..:||:::           .|..|:..||.|.            ....:
  Rat   129 KDTVSNK--QLMAKLQESKFDVLLSDPVAACGELIAEVLHIPFLYSLR------------FSPGY 179

  Fly   170 HIDYLAGN-LAPSVYEPISPNGFALDNTFLSRWSN---------WIYITEEKLLERLVFRPAQVR 224
            .|:..:|. :.|..|.|:..:|.....||:.|..|         |.::...|..:         .
  Rat   180 KIEKSSGRFILPPSYVPVILSGMGGPMTFIDRVKNMICTLYFDFWFHMFNAKKWD---------P 235

  Fly   225 LFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD 289
            .:.:..|.|. .|.|...:..:.|:.|::.:......:||:..:.|:. ..||:|...:::.::.
  Rat   236 FYSEILGRPT-TLAETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQ-CRPPKPLPKDMEDFVQ 298

  Fly   290 EA-EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQR 353
            .: |||.:.||:|.  ::..:.|.....:.....|:.|:|:||.:....|....|..|...:||.
  Rat   299 SSGEHGVVVFSLGS--MVSSMTEEKANAIAWALAQIPQKVLWKFDGKTPATLGPNTRVYKWLPQN 361

  Fly   354 MVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTL 418
            .:|.||..:.|:||||...|.|||.:|:||:|:|:|.:|.:||..:...|.|..|:...::...|
  Rat   362 DLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDL 426

  Fly   419 IETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYR 483
            ...:||::.||.|.:.|..::....|:||.|||.|::|.|:.:|::...|:|.....:|..:|:.
  Rat   427 FNALKEIINNPFYKKNAVWLSTIHHDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHNLPWYQYHS 491

  Fly   484 LDSILTFGVRLGC-------VCGSLIFLGWRLYQKNRNR 515
            ||.|   |..|.|       ...|.:|: :||:.|...:
  Rat   492 LDVI---GFLLTCSAVIAVLTVKSFLFI-YRLFVKKEKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	115/482 (24%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	130/540 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344087
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.690