DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	139/533 - (26%)
Similarity:	241/533 - (45%)	Gaps:	74/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLHLNLYLELGQAANILG---VFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKI---D 70
            |||...|...||.:|:..|   |.|.. .|.:..:..:|:.|.::||:|.::.|   .|.|   :
  Rat    12 LLLPCLLLCVLGPSASHAGKLLVIPID-GSHWLSMLGVIQQLQQKGHEVVVIAP---EASIHIKE 72

  Fly    71 G----VRHIRVPMLN--------QLMQNLMKNDQFFDALGDKW----REGVLV----STIFYNVS 115
            |    :|...||..|        :|.:::...|.|...:...:    |:..::    |.:.:|..
  Rat    73 GSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCSHLLHNAE 137

  Fly   116 H-AILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNL- 178
            . |.|..:....|:.|..:....|:.:...|.|:|    |.||    :.|     .:|..|...
  Rat   138 FMASLEQSHFDALLTDPFLPCGSIVAQYLSLPAVY----FLNA----LPC-----SLDLEATQCP 189

  Fly   179 APSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKL------ 237
            ||..|.|.|.:.......||.|..|.|....|..|.|:|:.|         :|..|.::
  Rat   190 APLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSP---------YGSLATEILQKEVT 245

  Fly   238 -DELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYFSM 300
             .:|.:..|:.|:.:.|.....|..:||::.:.|::..: .:....|.:.|:: ..|||.:.||:
  Rat   246 VKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQ-KKALSQEFEAYVNASGEHGIVVFSL 309

  Fly   301 GQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFI 365
            |.  ::..:||....::.....::.|.|:|:...:..:|.::|..::..:||..:|.||..|.||
  Rat   310 GS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFI 372

  Fly   366 THGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPS 430
            ||.|...:.|.|.|||||:.:|||.||.:|..|::..|....|:..::.||.|...:|.::.|.|
  Rat   373 THSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKS 437

  Fly   431 YAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSI-------- 487
            |.:....:::..:|||:.|||.|::|.||.:|::...|:|....::...:|:.||.|
  Rat   438 YKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVL 502

  Fly   488 -LTFGVRLGCVCG 499
             :.|.|...|..|
  Rat   503 TVVFIVYKSCAYG 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	123/475 (26%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	132/515 (26%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	71/248 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760