DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	535	Identity:	131/535 - (24%)
Similarity:	244/535 - (45%)	Gaps:	72/535 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADY----PA 67
            |::..|||.::..........:| |:|... |.:..::.::..||:|||:||::.|:..    |.
Mouse     5 WISALLLLQMSCCFRSTSCGKVL-VWPLEF-SHWMNLKIILDELVQRGHEVTVLRPSASIFVDPK 67

  Fly    68 KIDGVRHIRVPMLNQLMQNLMKN--DQFFDALGDKWREGV---------LVSTIF-----YNVS- 115
            ...|::....|..      ..|:  :.|...|.|:|...|         |:.|:|     |::|
Mouse    68 YSPGLKFETFPTA------FSKDYLETFLTKLVDEWTFEVPRDTCLSYSLLQTLFGKLSDYSLSL 126

  Fly   116 --HAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMT-----WHIDY 173
              .|:.|.   |::.:.:..:||:::     |||:....|.. |.||.|..::..     :.::.
Mouse   127 CKEAVSNK---QLMTKFQESKFDVLI-----LDAMASCGELI-AQLLQIPFLYSLRFSPGYQVEK 182

  Fly   174 LAGN-LAPSVYEPISPNGFALDNTFLSRWSN---------WIYITEEKLLERLVFRPAQVRLFKK 228
            .:|. :.|..|.|:..:|.....||..|..|         |.....||..:         :.:.:
Mouse   183 NSGGFVLPPSYVPVILSGLGGQMTFTERVKNMICMLYFDFWFQTFTEKEWD---------QFYSE 238

  Fly   229 FFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-E 292
            ..|.|. .|.|...:..:..:.|::.:......:||:..|.|:| .:|.:|...|::.::..: .
Mouse   239 TLGRPT-TLIETMGKAEMWFIRSYWDLEFPHPTLPNVEYVGGLH-CKPAKPLPKEMEDFVQSSGV 301

  Fly   293 HGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLA 357
            ||.:.||:|.  ::..:.|.....:.....|:.|:|:|:.:....|:...|..:...:||..:|.
Mouse   302 HGVVVFSLGS--MVSNMTEERANAISWALAQIPQKVLWRFDGKTPASLGPNTRIYKWLPQNDLLG 364

  Fly   358 HPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETI 422
            ||..:.|:||||...:.|||.:|:||:|:|||.:|.:||..:...|.|..|:...::...|:..:
Mouse   365 HPKTKAFVTHGGANGLYEAIHHGIPMIGIPLFSEQHDNIAHMVAKGTAVALNIRTMSRSDLLNAL 429

  Fly   423 KELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSI 487
            :|::.||||.:....::....|:||.||:..|:|.|:.:|::...|:|.....:...:|:.||.|
Mouse   430 EEVINNPSYKENVMWLSTIHHDQPMKPLNRTIFWIEFVMRHKGAKHLRPLAHNLTWYQYHSLDVI 494

  Fly   488 LTFGVRLGCVCGSLI 502
               |..|.||..:.:
Mouse   495 ---GFLLVCVVATAV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	117/478 (24%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	130/530 (25%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	127/516 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840444
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690