DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and Ugt2b36

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001025038.1	Gene:	Ugt2b36 / 231396	MGIID:	3576103	Length:	530	Species:	Mus musculus

Alignment Length:	554	Identity:	137/554 - (24%)
Similarity:	254/554 - (45%)	Gaps:	73/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YAWLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADY---- 65
            :.|::..|||.::......:...:| |:|... |.:..::.::..|.::||:||::.|:..
Mouse     3 WKWISALLLLQISCCFRSAKCGKVL-VWPVDY-SHWMNIKIILDELKQKGHEVTVLRPSTSIFLD 65

  Fly    66 PAKIDGVRHIRVP--MLNQLMQNLMKNDQFFDALGDKWREGV----------LVSTIFYNVSHAI 118
            |.|..|::....|  ..|.:|:.:      |....::|...|          |:..||...|...
Mouse    66 PKKSPGLKFETFPTSFSNDVMEII------FAKAVERWTYEVPRDTCLSYSPLLQNIFDEYSDYC 124

  Fly   119 L-----NNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMT-----WHIDY 173
            |     ..:..|::.:.:..:||:|:     .||:....|.. |.||.|..::..     ::::.
Mouse   125 LTLCKDTVSNKQLMAKLQESKFDVIL-----SDAIGPCGELI-AELLQIPFLYSLRFSPGYYLEK 183

  Fly   174 LAGNL-APSVYEPISPNGFALDNTFLSRWSN---------WIYITEEKLLERLVFRPAQVRLFKK 228
            .:|.| .|..|.|:..:|.:...||..|..|         |.....||..:         :.:.:
Mouse   184 YSGGLPLPPSYVPVILSGLSGQMTFKERVKNMICMLYFDFWFQTFREKKWD---------QFYSE 239

  Fly   229 FFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-E 292
            ..|.|. .|.|...:..:.|:.|::.:......:||:..|.||| .:|.:|...|::.::..: |
Mouse   240 TLGRPT-TLIETMGKAEMWLIRSYWDLEFPHPTLPNVYYVGGVH-CKPAKPLPKEMEDFVQSSGE 302

  Fly   293 HGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLA 357
            ||.:.||:|.  ::..:.|.....:.....|:.|:|:|:.:....|....|..:...:||..:|.
Mouse   303 HGVVVFSLGS--MVSNMTEEKANAIAWALAQIPQKVLWRFDGKTPATLGPNTRIYKWLPQNDLLG 365

  Fly   358 HPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETI 422
            ||..:.||||||...:.|||.:|:||:|:|||.:|.:||..:...|.|..|:...::...|:..:
Mouse   366 HPKTKAFITHGGANGLYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDLLNAL 430

  Fly   423 KELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSI 487
            :|:::||.|.:.|..::....|:||.|||.|::|.|:.:|::...|:|.....:...:|:.||.|
Mouse   431 EEVIDNPFYKENAMWLSTIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRPLAYNLTWYQYHSLDVI 495

  Fly   488 ------LTFGVRLGCVCGSLIFLGWRLYQKNRNR 515
                  :||.|.|...|  .:|: :|.:.|...:
Mouse   496 GFLLAFVTFIVALIVKC--FLFV-YRFFVKKEKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	119/476 (25%)
Ugt2b36	NP_001025038.1	egt	8..506	CDD:223071	130/524 (25%)
Ugt2b36	NP_001025038.1	UDPGT	24..527	CDD:278624	133/533 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840443
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690