DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_659094.1	Gene:	Ugt3a2 / 223337	MGIID:	2145969	Length:	523	Species:	Mus musculus

Alignment Length:	527	Identity:	125/527 - (23%)
Similarity:	233/527 - (44%)	Gaps:	65/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMV----------- 60
            ||   |:..|.|.:.|.:||.||.:.... .|.:.::..:.:.|.|.||.||.:
Mouse     7 WL---LMSFLFLEVILLEAAKILTISTLS-ASHYIVISRVSQVLHEGGHNVTKLLYESANIPDFR 67

  Fly    61 ------------TPADYPAKIDGVRH---IRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVSTI 110
                        .|.|...|...:||   ..:.........|:|..|:|   ||
Mouse    68 KEKPSYQVINWRPPEDQEKKFADLRHRLTEEITYGRSKHHTLLKIHQYF---GD----------- 118

  Fly   111 FYNVSHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLA 175
               :...:|:...:...:::::  ||::::::..|.:|. :.|......:..    :.:...|:.
Mouse   119 ---LCSQLLSRKDIMDFLKNEN--FDLVLLDSMDLCSLL-IVEKLGKRFVSF----LPFQFSYMD 173

  Fly   176 GNL--APSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLD 238
            ..|  ||..|.|:..:|......|..|..|::...:..:.:|.:.......:.:.|.......|.
Mouse   174 FGLPSAPLSYAPVYGSGLTDQMDFWGRVKNFLMFLDFSMKQREILSQYDSTIQEHFVEGSQPVLS 238

  Fly   239 ELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDE-AEHGAIYFSMGQ 302
            :|..:..:..|||.|::...|...||.:.|.|: |.:|.:|...:|:.::.: .:.|.:..::|
Mouse   239 DLLLKAELWFVNSDFALDFARPLFPNTVYVGGL-LDKPVQPIPQDLENFISQFGDSGFVLVALG- 301

  Fly   303 DILIKYLPENMQKQLLLVFLQMKQRVIWKSELSML---ANKSENIYVMDKVPQRMVLAHPNLRLF 364
            .|:.....:.:.|::...|..:.|.|:|..:.|..   .:.:.|:.:||.:||..:||||::|||
Mouse   302 SIVSMIQSKEIIKEMNSAFAHLPQGVLWTCKTSHWPKDVSLAPNVKIMDWLPQTDLLAHPSIRLF 366

  Fly   365 ITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENP 429
            :||||:.|||||:.:||||:|:|.||||..|:.||:...:...:....|.|::...|:|:::|:.
Mouse   367 VTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAESFALTMKKIIEDK 431

  Fly   430 SYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRL 494
            .|...|..........|::|....:.|.::.|:....:|::....:.|....|.||..|..   |
Mouse   432 RYKSAAMASKIIRHSHPLTPAQRLLGWIDHILQTGGAAHLKPYAFQQPWHEQYMLDVFLFL---L 493

  Fly   495 GCVCGSL 501
            |.:.|:|
Mouse   494 GLMLGTL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	109/471 (23%)
Ugt3a2	NP_659094.1	UDPGT	23..488	CDD:278624	112/491 (23%)
Ugt3a2	NP_659094.1	egt	<235..488	CDD:223071	73/254 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740