DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	557	Identity:	150/557 - (26%)
Similarity:	266/557 - (47%)	Gaps:	71/557 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTM-------VTPAD 64
            |.|.|          :.:||.|:.|.|....|...:.:.|..||.||||...:       :.|::
Mouse    12 WSAVG----------IARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSN 66

  Fly    65 ------YPAKIDGVRHIRVPMLNQLMQNLMKN--------DQFFDALGDKWREGVLVSTIFYNVS 115
                  ||...:....      :..:|:.|:|        .:..|.| |.:.:         |..
Mouse    67 HYSLQRYPGIFNSTTS------DAFLQSKMRNIFSGRLTAVELVDIL-DHYTK---------NCD 115

  Fly   116 HAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLA--GNL 178
            ..:.|...:|.|.::|   ||:::|:.:      .:..|..|.|||:.....:..:.|.|  |..
Mouse   116 MMVGNQALIQGLKKEK---FDLLLVDPN------DMCGFVIAHLLGVKYAVFSTGLWYPAEVGAP 171

  Fly   179 APSVYEPISPNGFALDN-TFLSRWSN-WIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELR 241
            ||..|.| ..|....|. .||.|..| .:|:.....:..||. |...|:.:|:...||:.:.:|.
Mouse   172 APLAYVP-EFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVL-PKYERIMQKYNLLPAKSMYDLV 234

  Fly   242 ARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDIL 305
            ...|:.::.:..::...|..:||::.|.|: |::|..|...:||:::..| |||.:..|.|..
Mouse   235 HGSSLWMLCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVSGAQEHGFVLVSFGAG-- 296

  Fly   306 IKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGL 370
            :|||.|::..:|.....::.|:|||:...:...|...|..:::.:||..:|.|.|:|.|::||||
Mouse   297 VKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGL 361

  Fly   371 QSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRA 435
            .|:.|.:.:|||::|:|||.|.::.:.|||..||..:|:.|.:....|.:.:.:::.||||.|||
Mouse   362 NSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRA 426

  Fly   436 KEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGS 500
            ::::...:|:|..|::...:|.:|.||:....|:|..|.:|...:|:.||  :.|.:.||.|...
Mouse   427 QKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLD--IAFVLLLGAVLLY 489

  Fly   501 LI--FLGWRLYQKNRNRHTRLQERERVIAQIQLGLSN 535
            .|  ::...:|:|.::..:: .|...|....|.|:.|
Mouse   490 FILSYVTKFIYRKIKSLWSK-NEHSTVNGHYQNGIRN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	128/465 (28%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	140/512 (27%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840742
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790