DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt2b5

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_033493.3	Gene:	Ugt2b5 / 22238	MGIID:	98900	Length:	530	Species:	Mus musculus

Alignment Length:	553	Identity:	137/553 - (24%)
Similarity:	260/553 - (47%)	Gaps:	75/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADY----PA 67
            |::..|||.::......:...:| |:|... |.:..::.::..||:|||:||::.|:.|    |.
Mouse     5 WISALLLLQISCCFRSVKCGKVL-VWPMEF-SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPK 67

  Fly    68 KIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDKW-----REGVL------------VSTIFYNVS 115
            |..|::....|  ..:.::.::|  ||....|.|     |:..|            .|..|.::.
Mouse    68 KSPGLKFETFP--TSVSKDNLEN--FFIKFVDVWTYEMPRDTCLSYSPLLQNMIDEFSDYFLSLC 128

  Fly   116 HAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMT-----WHIDYLA 175
            ..:::|.  :::.:.:..:||:::     .|.:....|.. |.||.|..::..     :.|:..:
Mouse   129 KDVVSNK--ELMTKLQESKFDVLL-----SDPVASCGELI-AELLQIPFLYSIRFSPGYQIEKSS 185

  Fly   176 GN-LAPSVYEPISPNGFALDNTFLSRWSN---------WIYITEEKLLERLVFRPAQVRLFKKFF 230
            |. |.|..|.|:..:|.....||:.|..|         |..:..:|..:         ..:.::.
Mouse   186 GRFLLPPSYVPVILSGLGGQMTFIERIKNMICMLYFDFWFQMFNDKKWD---------SFYSEYL 241

  Fly   231 GYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHG 294
            |.|. .|.|...:..:.|:.|::.:......:||:..|.|:| .:|.:|...::::::..: :||
Mouse   242 GRPT-TLVETMGQAEMWLIRSNWDLEFPHPTLPNVDYVGGLH-CKPAKPLPKDMEEFVQSSGDHG 304

  Fly   295 AIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHP 359
            .:.||:|.  ::..:.|.....:.....|:.|:|:||.:....|....|..|...:||..:|.||
Mouse   305 VVVFSLGS--MVSNMTEEKANAIAWALAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHP 367

  Fly   360 NLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKE 424
            ..:.|:||||...|.|||.:|:||:|:|||.:|.:||..:...|.|..|:...::...::..::|
Mouse   368 KTKAFVTHGGANGVYEAIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVALNIRTMSKSDVLNALEE 432

  Fly   425 LLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILT 489
            ::|||.|.:.|..::....|:||.|||.|::|.|:.:|::...|:|.....:...:|:.||.|
Mouse   433 VIENPFYKKNAMWLSTIHHDQPMKPLDRAVFWIEFVMRHKRAKHLRPLGHNLTWYQYHSLDVI-- 495

  Fly   490 FGVRLGCVCGS-------LIFLGWRLYQKNRNR 515
             |..|.||..:       |:|: :|.:.|..|:
Mouse   496 -GFLLSCVATTIVLSVKCLLFI-YRFFVKKENK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	118/476 (25%)
Ugt2b5	NP_033493.3	egt	8..489	CDD:223071	123/507 (24%)
Ugt2b5	NP_033493.3	UDPGT	24..527	CDD:278624	133/534 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840445
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690