DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	541	Identity:	140/541 - (25%)
Similarity:	242/541 - (44%)	Gaps:	96/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKIDG---- 71
            |||| |...|...:.|.:| |.|.. .|.:..:|.:::.|..|||: |:|..::....|.|
Mouse    14 GLLL-LLCALPWAEGAKVL-VLPME-GSQWLSMRDVVRELHARGHQ-TVVLASEVTVHIKGEDFF 74

  Fly    72 -VRHIRVPMLNQLMQNLMKND----------------------QFFDALGDKWREGVLVSTIFYN 113
             ::....|...:..|..:.:|                      .|||              ::.|
Mouse    75 TLKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFD--------------LYSN 125

  Fly   114 VSHAILNNNGVQMLMRD-KSIRFDMIMVEASHLDALYG----LAEFYNA----TLLGISCMHMTW 169
            ...|:|:|   :||::. .|..||:|:.     |.::.    ||::...    .|..:||
Mouse   126 SCIALLHN---KMLIQQLNSSFFDVILT-----DPIFPCGAVLAKYLQIPAVFILRSLSC----- 177

  Fly   170 HIDYLAGNLA-PSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYP 233
            .|:|.|.... ||.|.|......:....||.|..|.:|....|.:.||...|           |.
Mouse   178 GIEYEATQCPNPSSYIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITP-----------YE 231

  Fly   234 AEKLDELRARFSVILVNSHFSMGRVRAN---------VPNIIEVAGVHLSEPPEPCGAELQKYLD 289
            :...:.|:...|::.|.||.|:...|.:         :||::.:.|:: ....:|...|.:.|::
Mouse   232 SLASELLQREVSLVEVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGIN-CVTKKPLSQEFEAYVN 295

  Fly   290 -EAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQR 353
             ..|||.:.||:|.  ::..:||....::.....::.|.|:|:...:..:|.::|..::..:||.
Mouse   296 ASGEHGIVVFSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQN 358

  Fly   354 MVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTL 418
            .:|.||..|.||||.|...:.|.|.|||||:.:|||.||.:|..|::..|....|:..::.||.|
Mouse   359 DLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDL 423

  Fly   419 IETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYR 483
            ...:|.::.|.||.:....:::..:|||:.|||.|::|.||.:|::...|:|....::...:|:.
Mouse   424 ENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHS 488

  Fly   484 LDSILTFGVRLGCVCGSLIFL 504
            ||.|   |..|..|. :::|:
Mouse   489 LDVI---GFLLAIVL-TVVFI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	124/486 (26%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	134/526 (25%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	29/154 (19%)
		egt	<261..505	CDD:223071	73/250 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840628
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690