DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and ugt-18

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_506209.2	Gene:	ugt-18 / 179759	WormBaseID:	WBGene00013900	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	125/546 - (22%)
Similarity:	223/546 - (40%)	Gaps:	92/546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YAWLAFGLLLHLNLYLEL--------GQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVT 61
            :|.:.|.:|:|..|..::        ...:|.||              .:...|::.||.|||:.
Worm     3 FALILFFVLIHSTLTYKVLVFNPAYGASHSNFLG--------------KISDILIDAGHNVTMLI 53

  Fly    62 PADYPAKIDGVRHIRVPMLNQLMQNLMKNDQFFDALGDK-------WR---EGVLVSTIFYNVSH 116
            |.....|.|.|...:|..:.::.:: .:..:.|:..|.:       ||   |.:.:.||..:::.
Worm    54 PEYLITKKDFVGSKKVKDVVRIGRD-ERAGKLFEEEGIEHMGRARVWRMDPEMMSLVTIVGSMNL 117

  Fly   117 AILNNNGVQ--MLMRDKSI-------RFDMIMVEA---------SHLDALYGLAEFYNA--TLLG 161
            ||    |.|  .:.:.|.|       .||:.:.|:         .|:    |:....||  .|..
Worm   118 AI----GYQCEYIFQQKDIIDRLRNEHFDLAITESLFACPFALFDHI----GIKNVINAESNLFK 174

  Fly   162 ISCMHMTWHIDYLAGNLAPSVYEP--ISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVR 224
            .:       :.|..|..|...|.|  .||:...:  :|::|..|.|.:...|.|....:. .::.
Worm   175 DA-------VKYAHGEPAAISYYPGLFSPHDDKM--SFVARVKNMITMLFTKYLYGSRYE-KELE 229

  Fly   225 LFKKFFGYPAEKLDELRARFSVILVNSHFSMGRVRANVPNIIEVAG--VHLSEPPEPCGAELQKY 287
            :.|.::. ..|..::|....:..|:||:..:......:|..:.|.|  |:.:|.......|....
Worm   230 MIKPYYN-GTETWEDLFTGVAFNLINSNQYIDYPSPALPKTVFVGGMQVNTNEAKTKLSDEWNNI 293

  Fly   288 LDEAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQ-RVIWKSE--LSMLANKSENIYVMDK 349
            |:..:.. :..|.|.:.....:||..:|..|.||..|.: ..|||.|  .:.|.:...|:.:...
Worm   294 LNIRKQN-VLISFGSNAFSSEMPEEFKKSFLYVFGNMPEITFIWKYEEANATLTSHLPNVKLTTW 357

  Fly   350 VPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDL- 413
            :||..:||...|.||:|||||.|.||....|.|.|.:||..||..|.|.::..|.........|
Worm   358 MPQNDLLADDRLTLFVTHGGLGSTMELAYQGKPALIIPLMADQPRNAHMLKRHGGCLQYHKTMLG 422

  Fly   414 NADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPL 478
            :::.|::..|.:|....|::.|:.:|...||:|:||.|..:...|:|:.:...:.:......:..
Worm   423 DSEQLLKAFKTVLTERKYSENAQRLARILRDQPVSPKDLVLKHCEFAVEHGALNSLNSRGRYLNT 487

  Fly   479 MRYYRLDSILTFGVRLGCVCGSLIFL 504
            .::|..|           :..|::.|
Worm   488 FQFYSFD-----------IASSIVML 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	116/477 (24%)
ugt-18	NP_506209.2	UDPGT	19..512	CDD:278624	120/530 (23%)
ugt-18	NP_506209.2	Glycosyltransferase_GTB_type	<252..504	CDD:299143	69/263 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860