DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt-24

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	145/563 - (25%)
Similarity:	240/563 - (42%)	Gaps:	104/563 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AWLAFGLLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKID 70
            |.|.:.:|::.|||   |.             |..:::..:...|.:.||.||:..|....:::|
Worm    16 AALPYKILIYSNLY---GH-------------SHIKVLNTVADTLTDAGHNVTIFRPIIESSQLD 64

  Fly    71 --GVRHIRVPML---NQLMQNLMKNDQFFDALG--DKWREGVLVSTIFYNVSHAILNNNGVQ--M 126
              .|:...|..:   .::::.:.|.|||..:|.  |......:::.     |:|::...|.|  .
Worm    65 KSSVKTKNVIYIEPDEEVVEKMSKIDQFSGSLWTFDSTHPSAMIAK-----SNALVGFFGTQCKK 124

  Fly   127 LMRDKSI-------RFDMIMVEASHLD-ALYGLAEFY----NATLLGISCMHMTWHIDYLAGNLA 179
            :||.:.|       .||:.:.|.  :| ..|.:.|:.    :.|:|  ||:......|.|...:|
Worm   125 VMRQQKILDQLRDENFDLAITEP--VDGCAYAIFEYLKIRDHVTVL--SCVRFDHVSDILGQPIA 185

  Fly   180 PSVYEPISPNGFALDNTFLSRWSNWIY-----ITEEKLLERLVFRPAQVRLFKKFFGYP---AEK 236
            || |.|.:.:.|....|...|..|:|.     .|...:|::      :..:.|...|..   .|.
Worm   186 PS-YVPGTQSFFNDRMTMKERLLNFIQFYYGRFTFANILDQ------EYEMAKDILGIQRSWREV 243

  Fly   237 LDELRARFSVILVNSHFSMGRVRANVPN-----IIEVAG--VHLSEPPEPCGAELQKYLD---EA 291
            |.|....||     :|..:    .:.|:     ||.:.|  |..:|.    ..::.|..|   ..
Worm   244 LPEASFIFS-----NHIPV----LDFPSPTFDKIIPIGGFTVKTNEK----SLKIDKKWDAILNI 295

  Fly   292 EHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRV-IWKSE--LSMLANKSENIYVMDKVPQR 353
            ....:..|.|.:...|.:||..:|.||.||..|.... |||.|  ...:|...:|:::...:||.
Worm   296 RKKNVLISFGSNAKSKDMPEEYKKTLLRVFSSMPDTTFIWKYEDPNVNIAKNLDNVFISSWLPQN 360

  Fly   354 MVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDL-NADT 417
            .:||...:.:|:|||||.||||....|.|.:.:|:|.||..|...::..|.|.||...|| |.|.
Worm   361 ELLADSRVTVFVTHGGLASVMELALMGKPAIMIPIFADQGRNAQMLKRHGGAAVLQKTDLSNFDL 425

  Fly   418 LIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALR-----NRDTSHMRLNVEEIP 477
            :.:|:.::|..|||...||::|....::|.:..:..:...|:|.|     ..|......|:.|
Worm   426 VRDTLNDVLTKPSYKLNAKKLAEMLNNQPTNAKEVLVKHVEFAARFGKLPMLDNYGRHQNIVE-- 488

  Fly   478 LMRYYRLDSILTFGVRLGCVCGSLIFLGWRL--YQKNRNRHTR 518
               ||.:| |||.   :..|..|:.::..||  :..:|||.|:
Worm   489 ---YYFID-ILTI---ILSVLISVFYIFVRLLRFMLSRNRSTK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	121/487 (25%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	134/524 (26%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	79/274 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860