DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and ugt-28

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_491437.1	Gene:	ugt-28 / 172086	WormBaseID:	WBGene00015693	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	127/545 - (23%)
Similarity:	219/545 - (40%)	Gaps:	88/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKID---GVRHIRVPMLNQLMQNLM 88
            |||...|....|....:..|...|.||||.||.:.|...|.|.|   ||:..:..::.:..:.:|
Worm    19 NILVYSPAFAASHSNFLGKLADTLTERGHNVTYLMPVVDPEKRDECIGVKLTKDLVIVEPDEEMM 83

  Fly    89 K-------NDQFFDALGDKWREGVLVST-----IFYNVSHAILNNNGVQMLMRD-----KSIRFD 136
            .       |.:..:..   |:..:..|.     .|:|....:...|..:  .||     ||..||
Worm    84 SFKKGSTPNGEIMELF---WKSEMDSSNSRDMFSFFNSDMKLACRNFHK--RRDIFEQMKSRNFD 143

  Fly   137 MIMVEASHLDALYGLAEFYNA-----TLLGISCMHMTWHIDYLAGNLAPSVYEPIS----PNGFA 192
            :.::|..   .:.||. |..|     |:|..|.......:||:.        ||:.    |:||:
Worm   144 VAILEPV---TICGLG-FVKALGIEKTILASSSTFYDAVMDYIG--------EPLDYSYVPSGFS 196

  Fly   193 LDN---TFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFS 254
            :..   |...|:.||:.:.|..:....:| ..:::.:::|.|.......||.:..|:..||::..
Worm   197 VTGDVMTMAERYENWMVVKEINIALHDMF-DGEMKSYREFLGEDLPNWRELLSSASIFFVNANPF 260

  Fly   255 MGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEAE------------HGAIYFSMGQDILIK 307
            :...||.:...:.:.|:.::          .|::.|.:            ...:..|.|..:...
Worm   261 LDFPRAVLQKTVPIGGISIN----------LKWIKEQKLTKDWEDILEKRTKTVLISFGSMVKSA 315

  Fly   308 YLPENMQKQLLLVFLQMKQRVI---WKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGG 369
            |:|:..:..||.|...|.....   ::|:....|:...||:....|||..:|..|.|..|:||||
Worm   316 YMPKIWRNGLLEVIKSMPDVTFIFKYESDEVSFADGISNIHFSKWVPQTALLNDPRLSAFVTHGG 380

  Fly   370 LQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDL-NADTLIETIKELLENPSYAQ 433
            |.|.||...:|.|.:.:|:|.||..|...:........|..|.: |.....:.:.::|.:.||.:
Worm   381 LGSTMELAYSGKPGVVIPVFADQIRNARMIARHNGVIYLHKNSMENVKVTRKALTDVLYDESYKK 445

  Fly   434 RAKEMAASFRDRPMSPLDTAIWWTEYA-----LRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVR 493
            .|:::.....::|.||::..|.:||:.     ..|.|.....||..:......|.|.::....|
Worm   446 NAEKLTDILMNQPYSPMENVIKYTEFVGEHGPFPNTDPYGRHLNYFQKTFFDIYALFALFYISV- 509

  Fly   494 LGCVCGSLIFLGWR-LYQKNRNRHT 517
                 |::|.:..| :|||.|...|
Worm   510 -----GTIIAISIRFIYQKARKYFT 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	112/489 (23%)
ugt-28	NP_491437.1	UDPGT	40..536	CDD:278624	121/524 (23%)
ugt-28	NP_491437.1	egt	<193..472	CDD:223071	67/289 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860