DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	128/529 - (24%)
Similarity:	231/529 - (43%)	Gaps:	77/529 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LYLELGQAANILGVFPYRIP---SPFQMVRPLIKALVERGHKVTMVTP--------------ADY 65
            |:|.|.  .::||.....:|   |.:..::.:::.|.||||.:.::.|              ..:
  Rat    15 LFLVLW--GSVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKYYRRKSF 77

  Fly    66 PAKID-----------GVRHIRV--PM---LNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNV 114
            |...:           |..|...  |:   |.:...|::..|..|.:.....::...:|
  Rat    78 PVPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDMCFFSCQSLLKDSATLS------ 136

  Fly   115 SHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCM--HMTWHIDYLAGN 177
               .|..|....|..|.::...:|:.|...|.::|        ...|..|.  ||      |..:
  Rat   137 ---FLRENQFDALFTDPAMPCGVILAEYLKLPSVY--------LFRGFPCSLEHM------LGQS 184

  Fly   178 LAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQV---RLFKKFFGYPAEKLDE 239
            .:|..|.|.....|:...||..|.:|:|....|..|...::...::   .|.|:....||...:
  Rat   185 PSPVSYVPRFYTKFSDHMTFPQRLANFIANILENYLYHCLYSKYEILASDLLKRDVSLPALHQN- 248

  Fly   240 LRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLD-EAEHGAIYFSMGQD 303
                 |:.|:...|.....|..:||:|.:.|.:..:... ...|.:.|:: ..|||.:.||:|.
  Rat   249 -----SLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGN-LSQEFEAYVNASGEHGIVVFSLGS- 306

  Fly   304 ILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHG 368
             ::..:||....::.....::.|.|:|:...:..:|.::|..::..:||..:|.||..|.||||.
  Rat   307 -MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHS 370

  Fly   369 GLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQ 433
            |...:.|.|.|||||:.:|||.||.:|..|::..|....|:..::.||.|...:|.::.|.||.:
  Rat   371 GSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKE 435

  Fly   434 RAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVC 498
            ....:::..:|||:.|||.|::|.||.:|::...|:|....::...:|:.||.|   |..|..|.
  Rat   436 NIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVI---GFLLAIVL 497

  Fly   499 GSLIFLGWR 507
             :::|:.::
  Rat   498 -TVVFIVYK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	115/478 (24%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	128/526 (24%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	123/516 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860