DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and UGT2A1

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001376494.1	Gene:	UGT2A1 / 10941	HGNCID:	12542	Length:	737	Species:	Homo sapiens

Alignment Length:	514	Identity:	125/514 - (24%)
Similarity:	228/514 - (44%)	Gaps:	96/514 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VRPLIKALVERGHKVTM--------------------VTPADY-PAKIDG---------VRHIRV 77
            ::.:::.|::|.|.||:                    |.|..| .:.||.         :.|...
Human   246 IKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPT 310

  Fly    78 PM--------LNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAILNNNGVQMLMRDK-SI 133
            |:        |.:|:      |.||. :..:..:|||.:....    |.|...|..:|:.|. :|
Human   311 PLTIWAFYKELGKLL------DTFFQ-INIQLCDGVLKNPKLM----ARLQKGGFDVLVADPVTI 364

  Fly   134 RFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNLAPSVYEPISPN---GFALDN 195
            ..|::.::.. :..:|.| .|..|:.:...|..:...:.|:     |:....::..   |..:.|
Human   365 CGDLVALKLG-IPFMYTL-RFSPASTVERHCGKIPAPVSYV-----PAALSELTDQMTFGERIKN 422

  Fly   196 T---------FLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNS 251
            |         |.|.|..|                  ...:.|..|.|. .|.|...:..:.|:.:
Human   423 TISYSLQDYIFQSYWGEW------------------NSYYSKILGRPT-TLCETMGKAEIWLIRT 468

  Fly   252 HFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYLPENMQK 315
            ::.....|..:||...|.|:| .:|.:|...|:::::..: ::|.:.||:|.  ::|.|.|....
Human   469 YWDFEFPRPYLPNFEFVGGLH-CKPAKPLPKEMEEFIQSSGKNGVVVFSLGS--MVKNLTEEKAN 530

  Fly   316 QLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNG 380
            .:.....|:.|:|:|:.:....|....|..:.|.:||..:|.||..:.||||||...:.|||.:|
Human   531 LIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 595

  Fly   381 VPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDR 445
            |||:|:|:|.||.:||..::..|.|..::.|.:.:..|:..::.::..|||.:.|..::....|:
Human   596 VPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQ 660

  Fly   446 PMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFL 504
            |:.|||.|::|.|:.:|::...|:|:...::...:|:.||.|   |..|.||. :.|||
Human   661 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVI---GFLLVCVT-TAIFL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	112/472 (24%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	125/514 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150202
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690