Protein Alignment Ugt303B2 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_651154.1
• Gene: Ugt303B2 / 42776
• FlyBaseID: FBgn0039087
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 125/514 - (24%)
• Similarity: 228/514 - (44%)
• Gaps: 96/514 - (18%)

  Fly    43 VRPLIKALVERGHKVTM--------------------VTPADY-PAKIDG---------VRHIRV 77
            ::.:::.|::|.|.||:                    |.|..| .:.||.         :.|...
Human   246 IKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPT 310

  Fly    78 PM--------LNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAILNNNGVQMLMRDK-SI 133
            |:        |.:|:      |.||. :..:..:|||.:....    |.|...|..:|:.|. :|
Human   311 PLTIWAFYKELGKLL------DTFFQ-INIQLCDGVLKNPKLM----ARLQKGGFDVLVADPVTI 364

  Fly   134 RFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNLAPSVYEPISPN---GFALDN 195
            ..|::.::.. :..:|.| .|..|:.:...|..:...:.|:     |:....::..   |..:.|
Human   365 CGDLVALKLG-IPFMYTL-RFSPASTVERHCGKIPAPVSYV-----PAALSELTDQMTFGERIKN 422

  Fly   196 T---------FLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRARFSVILVNS 251
            |         |.|.|..|                  ...:.|..|.|. .|.|...:..:.|:.:
Human   423 TISYSLQDYIFQSYWGEW------------------NSYYSKILGRPT-TLCETMGKAEIWLIRT 468

  Fly   252 HFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYLPENMQK 315
            ::.....|..:||...|.|:| .:|.:|...|:::::..: ::|.:.||:|.  ::|.|.|....
Human   469 YWDFEFPRPYLPNFEFVGGLH-CKPAKPLPKEMEEFIQSSGKNGVVVFSLGS--MVKNLTEEKAN 530

  Fly   316 QLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNG 380
            .:.....|:.|:|:|:.:....|....|..:.|.:||..:|.||..:.||||||...:.|||.:|
Human   531 LIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 595

  Fly   381 VPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDR 445
            |||:|:|:|.||.:||..::..|.|..::.|.:.:..|:..::.::..|||.:.|..::....|:
Human   596 VPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQ 660

  Fly   446 PMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFL 504
            |:.|||.|::|.|:.:|::...|:|:...::...:|:.||.|   |..|.||. :.|||
Human   661 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVI---GFLLVCVT-TAIFL 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	Glycosyltransferase_GTB-type	24..464	CDD:471961	112/472 (24%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	125/514 (24%)