DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	529	Identity:	126/529 - (23%)
Similarity:	233/529 - (44%)	Gaps:	65/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLHLNLYLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPA------------- 63
            |||.|:.:...|....:| |:|... |.:..::.::..|:::||:|.::.|:
Mouse    12 LLLQLSGFFGSGTGGKVL-VWPMEF-SHWLNLKTILDELLKKGHEVMVLRPSASLSYEVDNTSAI 74

  Fly    64 ---DYPA--KIDGVRHIRVPMLNQLMQNLMKND--QFFDALGD------KWREGVLVSTIFYNVS 115
               .||.  .:..:..|....|.:.:..|.|..  .:|..|.:      |:.|.:....:|....
Mouse    75 EFETYPTSYSLSELEEIFWESLKKYIYELPKQSFWGYFLMLQEMVWVDSKYFESLCKDVVFNKEL 139

  Fly   116 HAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWHIDYLAGNLAP 180
            ...|..:...:::.|..|....::.|...:..:|.|..|..:|           :..|..|...|
Mouse   140 MTKLQKSRFDVILADPFIPCGDLLAEVLKIPLVYSLRFFPGST-----------YEKYSGGLPLP 193

  Fly   181 SVYEPISPNGFALDNTFLSRWSNWIYIT---------EEKLLERLVFRPAQVRLFKKFFGYPAEK 236
            ..|.|:..:..:...||:.|..|.||:.         .||...         :|:.:..|.|. .
Mouse   194 PSYVPVVMSELSDRMTFMERVRNVIYMLCFDFWFQTFNEKNWN---------QLYTEVLGRPT-T 248

  Fly   237 LDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSM 300
            |.|..|:..:.|:.:::.:......:||...:.|:| ..|.:|...|::.::..: |||.:.||:
Mouse   249 LSETMAKADIWLIRTYWDLEFPHPVLPNFDFIGGLH-CRPAKPLPKEIEDFVQSSGEHGVVVFSL 312

  Fly   301 GQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFI 365
            |.  ::..:.|.....:.....|:.|:|:|:.|.........|..:...:||..:|.|...|.||
Mouse   313 GS--MVGSITEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDLLGHSKTRAFI 375

  Fly   366 THGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPS 430
            ||||...:.|||.:|:|::|:|||.||::||..::..|.|..||...:::..|...:|.:..:||
Mouse   376 THGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKAKGAAVRLDFLTMSSTDLHTALKTVTNDPS 440

  Fly   431 YAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLG 495
            |.:.|..::....|:|:.|||.|::|.|:.:|::...|:|:...::..::|:.||   ..|..|.
Mouse   441 YKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWVQYHSLD---VLGFLLA 502

  Fly   496 CVCGSLIFL 504
            ||...:..|
Mouse   503 CVLTVMFIL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	111/475 (23%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	121/514 (24%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	72/243 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840442
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690