DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	511	Identity:	135/511 - (26%)
Similarity:	239/511 - (46%)	Gaps:	99/511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LIKALVERGHKVTMVTPAD-YPAKIDGVRH--IRVP----MLNQLMQNLMKNDQFFDALGDKWRE 103
            |||||..:||.|.::...: :..|.:...:  |.:|    |..:.:::::.....::.....|..
Zfish    46 LIKALHGQGHTVDVIRNTNSWFVKENSTYYNSITIPDSKGMDEEFVEDVLTKKIDYERGKGSWLG 110

  Fly   104 GVLVSTIFYNVSHA--------------ILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEF 154
            ||   .:|.:||.|              |..:..:...:::|  ::|:::.     |..:|
Zfish   111 GV---QLFLDVSKAVYESHKLVCRLITNIFESEDILKALQEK--KYDLMLT-----DPGWG---- 161

  Fly   155 YNATLLGISCMH---------MTW------HIDYLAGNLAPS--VYEPISPNGFALDNTFLSRWS 202
                 .||...|         :.|      |.|     :|||  .|.|::.:|.....:|..|..
Zfish   162 -----TGIILAHKLKLPMVYNVRWTTPGEGHFD-----IAPSPMSYIPLTGSGNTDKMSFFQRVI 216

  Fly   203 NWIYITEEKLLERLVFR---PAQVRLFKKFFGYPAEKLDELRARFSVILVNSHFSMGRV------ 258
            |..|..   ||:....|   |....|..|:|..|.:        |..:|..:...:.||
Zfish   217 NVFYYL---LLDFQCSRFNVPQYQALCDKYFDPPVD--------FYKLLQGADLWLMRVDFVFEF 270

  Fly   259 -RANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIKYLPENMQKQLLLVF 321
             |..:||||...|...: |.:|...:|:.::..: :||.|..|:|.  .|..||:.:..::...|
Zfish   271 PRPTMPNIIYTGGFQCT-PTKPLPHDLEDFMQSSGDHGVIVMSLGS--FISVLPDYVSSEIAAAF 332

  Fly   322 LQMKQRVIWK---SELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPM 383
            .::.|:|||:   .:.|.|.|   |..::|.:||:.:|.||..:|||.|||...|.||:.:|||:
Zfish   333 ARLPQKVIWRYTGKKPSTLGN---NTLLVDWMPQKDLLGHPKTKLFIAHGGTNGVQEALYHGVPV 394

  Fly   384 LGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKEMAASFRDRPMS 448
            :|:|.||||::|:.|:|..|.||::...:|..::|...|:|::..|||....::::...||:|:.
Zfish   395 IGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIQEVINEPSYRLNMQKLSYLHRDKPVE 459

  Fly   449 PLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILTFGVRLGCVCGSLIFL 504
            |||:||:|.|:.:|::..:|:|....::|...|:.:|..:|.      :...|||:
Zfish   460 PLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVSVTL------IAVVLIFI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	126/469 (27%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	135/511 (26%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	80/251 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585093
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690