DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B2 and ugt1a4

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001170815.2	Gene:	ugt1a4 / 100384901	ZFINID:	ZDB-GENE-080227-3	Length:	520	Species:	Danio rerio

Alignment Length:	528	Identity:	143/528 - (27%)
Similarity:	249/528 - (47%)	Gaps:	94/528 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAFGLLLHLNLYLELGQA-ANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTP-------- 62
            ||..||.|       ||.| |..|.|.| ...|.:..::|:::.|..||::|.:|.|
Zfish     5 WLLVGLFL-------LGSAEAGKLLVIP-SDGSHWLGMKPVVEELGRRGNQVVVVIPEASLSMGP 61

  Fly    63 ------ADYPAKIDGVRHIRVPMLNQLMQNL---MKND---------QFFDALGDKWREGVLVST 109
                  ..||     |.:.:..:...|..||   :..|         .||..|      .||.:.
Zfish    62 SEKTTTLTYP-----VNYTKAELHMVLEGNLTEILSTDFSTEVSKFFVFFLQL------KVLQNF 115

  Fly   110 IFYNVSHAILNNNGVQMLMRDKSIRFDMIMVEASHLDALYGLAEFYNATLLGISCMHMTWH---- 170
            |..|....:.|.:   ::.:.:..|||.|:.:.  .:.:..:|..|    |.|..::|..:
Zfish   116 IVRNAEGLLFNED---LMKKLQDCRFDAILTDP--FEPVGVIASEY----LSIPAIYMQVNLPCG 171

  Fly   171 IDYLAGNL-APSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPA 234
            :|.||... :|..|.| ..|....|.  ::.|...|.:. ..||:.:..|            |..
Zfish   172 VDSLASQCPSPPSYVP-QRNTHFTDQ--MNIWQRCINLV-RTLLQHMACR------------YMY 220

  Fly   235 EKLDELRARF-----SVI---------LVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQ 285
            .:.||:.:||     |::         |:...|:....|..:||::.:.|: .::.|:|...||:
Zfish   221 AEADEIASRFLQRRASIVEIMNRATLWLMRFDFAFEFPRPLMPNMVMIGGM-ATKKPKPLSKELE 284

  Fly   286 KYLD-EAEHGAIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDK 349
            :::: ..|||.:.|::|.  ::..|||...::....|.|:.|||:|:....:..|..:|:.:|..
Zfish   285 EFVNGSGEHGFVVFTLGS--MVSQLPEAKAREFFEAFRQIPQRVLWRYTGPVPENAPKNVKLMKW 347

  Fly   350 VPQRMVLAHPNLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLN 414
            :||..:|.||.:|.|:||||...:.|.|.|||||:.||||.||.:|..|:...|:|:.|...|:.
Zfish   348 LPQNDLLGHPKVRAFVTHGGSHGIYEGICNGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVT 412

  Fly   415 ADTLIETIKELLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLM 479
            ::.|:..:|:::.:.||.::..:::|..||||:.|||.|::|||:.:|::...|:|....::..:
Zfish   413 SEKLLVALKKVINDKSYKEKMMKLSAIHRDRPIEPLDLAVFWTEFVMRHKGAEHLRPAAHDLNWI 477

  Fly   480 RYYRLDSI 487
            :|:.||.|
Zfish   478 QYHSLDVI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	130/486 (27%)
ugt1a4	NP_001170815.2	UDPGT	19..508	CDD:278624	134/507 (26%)
ugt1a4	NP_001170815.2	egt	<229..497	CDD:223071	83/260 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930