DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B2 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	552	Identity:	146/552 - (26%)
Similarity:	254/552 - (46%)	Gaps:	82/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYP-------AKIDGVRHIRV 77
            :::|.:..:| |.|... |.:..:|.:|:|||:|.|.||::..:..|       |:.|  .|:
Zfish    15 VDVGWSGRVL-VMPGEY-SHWHNMRAIIEALVDRNHSVTVLVGSSSPTVPHTQKARFD--YHV-- 73

  Fly    78 PMLNQLMQNLMKNDQFFDALGDKWREGV------------LVSTIFYNVSHAILNNNGVQMLMRD 130
                 ...|:.|.:.  ||:   |.:.:            .||.||..:|..        |.:.|
Zfish    74 -----FKVNIEKEEA--DAV---WSDFIYLWMNETATKYETVSNIFQVMSRF--------MTLTD 120

  Fly   131 K----SIRFDMI-MVEASHLDALYG---------LAEFYNATLLGISCMHMTWHIDYLAGNL-AP 180
            :    ..:.|:: |:..||.|.|:.         :|:..|..|:........:..:.:.|.: ||
Zfish   121 EVCKGMFKEDLLQMLRESHYDVLFSDPMMPCSDLMAQTLNIPLVLSLRATFAYSFERMCGQMPAP 185

  Fly   181 SVYEPISPNGFALDN--TFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGYPAEKLDELRAR 243
            ..|.|.:.....|.:  :|:.|..|.:......:..:|.......|::.:..|.|. .:.|...:
Zfish   186 PSYVPAASLRDHLTDRMSFMERVENMLLYFSHDVFFKLYMMFTFDRIYTEIRGKPT-TMCETMGK 249

  Fly   244 FSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEA-EHGAIYFSMGQDILIK 307
            ..:.|:.:::.....|...||...|.|:| .:|.:|...|:::::..: :||.:.||:|.  :||
Zfish   250 ADIWLIRTYWDFEYPRPFPPNFKFVGGLH-CKPAKPLSKEMEEFVQSSGDHGVVVFSLGS--MIK 311

  Fly   308 YLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHPNLRLFITHGGLQS 372
            .|.......:.....|:.|:|:|:.........:.|..:.|.:||..:|.||..:.||||||...
Zfish   312 NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNG 376

  Fly   373 VMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKELLENPSYAQRAKE 437
            :.|||.:||||:|||||.||.:|:..::..|.|.|||.|.|.:..|::.:|.:|.||||.:....
Zfish   377 LYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMR 441

  Fly   438 MAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLD---------SILTF-GV 492
            ::....|:||.|||.|::|.|:.:||:...|:|:...|:...:|:.||         :::|| .|
Zfish   442 LSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAALITFLWV 506

  Fly   493 RLGCVCGSLIFLGWRLYQKNR-NRHTRLQERE 523
            :..|      ||..|..:|.| .|.|:..:.|
Zfish   507 KACC------FLFRRCVRKTRPERKTQKSKNE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	126/476 (26%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	140/531 (26%)
		REC	<129..>178	CDD:302758	9/48 (19%)
		egt	<254..485	CDD:223071	78/233 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585021
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930