DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and ugt5b4

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001074161.1	Gene:	ugt5b4 / 791210	ZFINID:	ZDB-GENE-070112-2332	Length:	531	Species:	Danio rerio

Alignment Length:	541	Identity:	141/541 - (26%)
Similarity:	251/541 - (46%)	Gaps:	61/541 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSLCLLL-QHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLI--------------- 58
            ::||||| .....::.|:| :||... |.:..|..||..|..:|||:|:|
Zfish    12 VTLCLLLVMAPVVESGNVL-VFPVDG-SHWVNMNILVEALHAKGHNITVIRMSDSWYIKEFSPHY 74

  Fly    59 TPI------GMPNDIEGVRHIRVAQLNERIKEMLESDQV---LDFMINKWTESALTAKALFNASN 114
            |.|      |...||       :.....|:..:|.....   |...:..|..|....:.......
Zfish    75 TSITLKSSGGFSEDI-------LETFASRLITILRDGSTWGRLKLEMEMWQSSLKIMETEREMII 132

  Fly   115 DILSDPGVQRMLHD-KSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTY---ELAGN 175
            :::.|   |:::.. |...:||.:.:|    |:||.|...|...:.: ...:.|..:   .....
Zfish   133 NMIED---QQLIDSLKKTKYDLFLTDP----AMYGGVILGNYLKLPI-VYNVRWAIFGEGHFVIA 189

  Fly   176 PAPSIYEPISPVGFSLETSLFSRVYNWI-HIMEEKLVNYLILRPAQLHLFQKFFGYSAQKMNELR 239
            |:|..|.|::.:......|...||.|.: :|:.|..:.:|| .|....|.::|.|......|.::
Zfish   190 PSPLSYVPVAMLELPDRMSFLERVKNVVMYIITETQIAFLI-APTYNVLCERFIGPGVNLFNLVQ 253

  Fly   240 SRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSMGNDIL 303
            .. .|.|..:.:.....|...|||:.:.|.. .:|.:|..::|:.|:..: |||||..|:|.  :
Zfish   254 GA-DLWLHRADFVFEYPRPTMPNIVYMAGFQ-CKPSKPLPKDLEDFVQSSGDHGVIVMSLGT--I 314

  Fly   304 IKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGL 368
            |..||:::.|.:.:.||.|.:.|||:.:........:|..:::..||..:|.||..|.|:.:||.
Zfish   315 IGQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGGT 379

  Fly   369 LSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKA 433
            ..|.||:..|||::|..:.|||..|:..:::.|.|:.:|..:::|::..:|:|.:|.:.||....
Zfish   380 NGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEVLYDPSYRENM 444

  Fly   434 KEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAAS 498
            :.:|:..||.|:.|||.|::|.|:.:|::....:|....::|...|:.:|.||..     :.|.|
Zfish   445 QRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVL-----ISAVS 504

  Fly   499 LIFLVYTLFLKY---RIRLRR 516
            ||.|.....::|   :|.:|:
Zfish   505 LIILSIYAVIRYFCCKICMRK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	122/470 (26%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	129/502 (26%)
ugt5b4	NP_001074161.1	egt	12..501	CDD:223071	133/515 (26%)
ugt5b4	NP_001074161.1	UDPGT	27..531	CDD:278624	136/526 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.790