DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	546	Identity:	145/546 - (26%)
Similarity:	261/546 - (47%)	Gaps:	86/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLI-------------- 58
            |.|.||:|   .|:.|..:| :.|... |.:..|:.|:..|.:|||::|::
Zfish     9 LFLLLCVL---SRSYAGKLL-VVPVEG-SHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPL 68

  Fly    59 -TPIGMPNDI-------EGVRHIRVAQLNERI--KEMLESDQVLDFMINKWTESALTAKALFNAS 113
             |.|.:.|.:       :.:.|:...|...:.  .||..:|:::.|:.....:|......||  .
Zfish    69 YTSITVDNGVFDDDFMEKFLPHLLKIQRQGKSFWNEMALADEMIHFVTETHKQSCNMTAILF--E 131

  Fly   114 NDILSDPGVQRMLHDKSESFDLIIMEPSSLDALYG---LVEFYNATLMGLSSI-RINWHTY---- 170
            |:.|       |...|..::|:::.:|:     ||   |:    |..:||..: .:.|..|
Zfish   132 NETL-------MNSLKDAAYDVVLTDPA-----YGSGVLL----AHRLGLPLVYNVRWTVYGEAH 180

  Fly   171 -ELAGNPAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILR---------PAQLHLFQ 225
             ::|  |:|..|.|:|.:..:.:.:...||.|        ::.|:::|         |.| .|.|
Zfish   181 FDIA--PSPLSYVPVSGLQLTDKMTFSQRVMN--------MMTYIMIRYKYSKNFGSPYQ-ELTQ 234

  Fly   226 KFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA- 289
            |:||.:....:.|:.. .|.|:.:.::....|...||::.:||.. .:|.:|...:|::|:..:
Zfish   235 KYFGPNVNFFSLLQDA-DLWLMRNDFTFEFPRPTMPNVVYMGGFQ-CKPAKPLPGDLEEFVQSSG 297

  Fly   290 DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHIL 354
            :||||..|:|. :..:.|.| :.:.:...||.|.:.:||:.......:..:|..:|...||..:|
Zfish   298 EHGVIMMSLGT-VFGQLLSE-LNDEIAAAFAQLPQKVIWRYTGPRPANLGNNTLIVNWLPQNDLL 360

  Fly   355 NHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTET 419
            .||..:||:.:||...:.||:..|||::|||:.|||..|:..::..|.|::::..:|::....|.
Zfish   361 GHPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEFATLDRAVFLEA 425

  Fly   420 IKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDS 484
            :|.:|.|.||....:.:|:...|:||.|||.|::|.|:.:||:....:|.....:..|||..||.
Zfish   426 LKEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSIDV 490

  Fly   485 ILAFSLRFGLVAASLIFLVYTLFLKY 510
            ||...|   :|...::..|||  :||
Zfish   491 ILTLML---MVLVFVLLTVYT--MKY 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	123/483 (25%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	135/513 (26%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	138/530 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584437
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690