DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	555	Identity:	146/555 - (26%)
Similarity:	254/555 - (45%)	Gaps:	83/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSLCLLL-QHDRAQAANILGIFP--YRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVR 71
            |.:|||| ..|...:..:| :.|  |.|   :..|:|::..|..:.|:||::.....|.    |.
Zfish     6 LLVCLLLCGVDVGWSGRVL-VMPGEYSH---WHNMRPVIEALVDKNHSVTVLVGSSSPT----VP 62

  Fly    72 HIRVAQLNERI----KEMLESDQVLDFMINKWTESALTAK-----------ALFNASNDI----L 117
            |.:..:....:    .|..|:|..:..||:.:|... .||           :.|....|:    |
Zfish    63 HTQKERFEYHVFKVNMEKEEADAAMRDMIHLFTNDT-AAKYEGEFVMWKVMSKFVEFGDVYFRGL 126

  Fly   118 SDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLS-----SIRIN--WHTYELAGN 175
            .|.|:.:.|.|  .::|::..:|        ::.|.:.....|:     |:|..  :....|.|.
Zfish   127 FDVGLLKTLRD--SNYDVLFSDP--------MMPFSDLMAQKLNIPQVISMRATFAYAAERLCGQ 181

  Fly   176 -PAPSIYEPISPVGFSLETSLFSRVYNWIHIME--EKLVNYLILRPA-QLHLFQKFFGYSAQ--- 233
             |||..|.|        ..:|...:.:.:..||  |.::.|::...| .|.....|.||.::
Zfish   182 MPAPPSYVP--------AVALTDHLTDRMSFMERVENMLLYIVHSIAFPLVATFTFDGYYSEILG 238

  Fly   234 ---KMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVI 294
               .|.|...:..:.||.:::.....|...||...||||| .:|.:|..:||::|:..: ||||:
Zfish   239 KPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFKFVGGLH-CKPAKPLSKELEEFVQSSGDHGVV 302

  Fly   295 YFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNV 359
            .||:|:  :||.|.......:......:.:.::|:.........:.|..:.:..||..:|.||..
Zfish   303 VFSLGS--MIKNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKT 365

  Fly   360 RLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHML 424
            :.|||:||...:.||:..||||:|||:|.||..|:..::..|.|.|:||:::....|.:.:|.::
Zfish   366 KAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHTMGSKDLVDALKAVV 430

  Fly   425 ANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFS 489
            .|.||......:|:...|:||.|||.||:|.|:.:||:....:|:...|:...:|:.:| :.||.
Zfish   431 NNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLD-VAAFL 494

  Fly   490 LRFGLVAASLIFLVYTLFLK-----YRIRLRRLHP 519
            |       |:..|:..|::|     :|..:|:..|
Zfish   495 L-------SITALITFLWVKACCFLFRRCVRKTRP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	125/479 (26%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	133/511 (26%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	138/535 (26%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	75/238 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690