DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and UGT2B17

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001068.1	Gene:	UGT2B17 / 7367	HGNCID:	12547	Length:	530	Species:	Homo sapiens

Alignment Length:	545	Identity:	126/545 - (23%)
Similarity:	246/545 - (45%)	Gaps:	88/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLTLSLCLLLQ--HDRAQAANILGIFP--YRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDI 67
            |:::.|.:.|.  ........:| ::|  |.|   :..|:.::..|..|||.|.::|
Human     5 WMSVFLLMQLSCYFSSGSCGKVL-VWPTEYSH---WINMKTILEELVQRGHEVIVLT-------- 57

  Fly    68 EGVRHIRVAQLNERIK-----EMLESDQVLDF---MINKWTESAL--TAKALFNASNDI---LSD 119
            .....:..|..:..||     ..|..:.:.||   |.::||.|..  |..:.|:...::   .||
Human    58 SSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSD 122

  Fly   120 PGV---------QRMLHDKSES-FDLIIMEPSSLDALYG----LVEFYNATLMGLSSIRIN-WHT 169
            ..:         ::::....|| ||:::     .||:..    |.|..|...  |.|:|.: .:|
Human   123 YNIKLCEDAVLNKKLMRKLQESKFDVLL-----ADAVNPCGELLAELLNIPF--LYSLRFSVGYT 180

  Fly   170 YELAGNP--APSIYEPISPVGFSLETSLFSRVYNWIHIME-------------EKLVNYLILRPA 219
            .|..|..  .|..|.|:.....|.:.....|:.|.|:::.             ::..:.::.||.
Human   181 VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPT 245

  Fly   220 QLHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQK 284
            .|.              |...:..:.||.:::.....|...||:..||||| .:|.:|..:|:::
Human   246 TLF--------------ETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLH-CKPAKPLPKEMEE 295

  Fly   285 FLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQA 348
            |:..: ::|::.||:|:  :|..:.|....::....|.:.:.::|:.:.........|..:.:..
Human   296 FVQSSGENGIVVFSLGS--MISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWL 358

  Fly   349 PQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNK 413
            ||..:|.||..:.|||:||...:.||:..|:||:|:|:|.||..|:..::..|.|..:||.:::.
Human   359 PQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSS 423

  Fly   414 DTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIE 478
            ..|...:|.::.:..|.....::|:...|:|:.|||.||:|.|:.:|::....:|:....:..|:
Human   424 RDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQ 488

  Fly   479 YYRIDSILAFSLRFGLVAASLIFLV 503
            |:.:| ::||.|   ...|::||::
Human   489 YHSLD-VIAFLL---ACVATMIFMI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	113/486 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	119/507 (23%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	123/526 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690