DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001365304.1	Gene:	Ugt1a8 / 613123	MGIID:	3576090	Length:	530	Species:	Mus musculus

Alignment Length:	525	Identity:	125/525 - (23%)
Similarity:	244/525 - (46%)	Gaps:	58/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITP-----IGMPND- 66
            |.|.:||||....|||..:| :.|... |.:|.|:.:|..|:.|||.|.::.|     :|...:
Mouse    10 LPLRVCLLLAFGLAQAGRLL-VVPMDG-SHWFSMKMIVEKLSHRGHEVVVVIPEVSWHLGKSQNF 72

  Fly    67 ----------IEGVRHIRVAQLNERIKEMLESDQVLDFMINKWTESALTAKALFNASNDILSDPG 121
                      :|.:.|    ..|....:..|:.:|..|.:.|.:.... .:.||:....:.:|..
Mouse    73 TVKTYSVSYTLEDLSH----HFNFFAHKQWENREVGMFSLLKHSGKGF-FQVLFSHCRSLFNDKK 132

  Fly   122 VQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSIYEPISP 186
            :...|  |..|||.:.::|..:..| .:.::::...:..|......:..|.|..|:|..|.|...
Mouse   133 LVEYL--KQRSFDAVFLDPFDVCGL-TIAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSYVPRIL 194

  Fly   187 VGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQK-----------MNELRS 240
            ..|:...:...||:|:...|:|:             .|..:|..:|.:           |.:|.|
Mouse   195 SKFADTMTFKERVWNYFSYMKER-------------AFCPYFFKTAIEIASEVLQTPVTMTDLFS 246

  Fly   241 RFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGVIYFSMGNDILI 304
            ..|:.:..:.:.:...|...||::.:||:: ..|.:|..:|.:.::: ..:||::.||:|:  ::
Mouse   247 SVSIWMFRTDFVLEFPRPVMPNMVYIGGIN-CHPGKPLSKEFEAYVNASGEHGIVVFSLGS--MV 308

  Fly   305 KFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLL 369
            ..:||.....:.:....:.::::|:.......:.:.|..:|:..||..:|.||..|.|||:.|..
Mouse   309 SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSH 373

  Fly   370 SVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAK 434
            .:.|.:.:||||:.:|:|.||..|.:.::..|....:::..:..|.|...:|.::.|.||.....
Mouse   374 GIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIM 438

  Fly   435 EISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASL 499
            .:|...||||:.|||.||:|.||.:|::....:|....::...:|:.:| ::.|.|   .:..::
Mouse   439 RLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGFLL---AIVLTV 499

  Fly   500 IFLVY 504
            :|:|:
Mouse   500 VFIVF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	112/468 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	112/492 (23%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	116/509 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.640